高级人 BBB-on-a-Chip：阿尔茨海默病研究的新平台。
Advanced Human BBB-on-a-Chip: A New Platform for Alzheimer's Disease Studies.
机构信息
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Biochip Development Division, Mepsgen Co. Ltd., Seoul, 05836, Republic of Korea.
出版信息
Adv Healthc Mater. 2021 Aug;10(15):e2002285. doi: 10.1002/adhm.202002285. Epub 2021 Jun 2.
Abstract
The blood-brain barrier (BBB) is a unique vascular structure that serves as a molecular transport gateway for the maintenance of brain homeostasis. Chronic disruption or breakdown of the BBB reportedly leads to neurodegenerative diseases. Nonetheless, research on human BBB pathophysiology and drug development remains highly dependent on studies using inherently different animals. Moreover, more studies have shown that animal models are not appropriate in modeling Alzheimer's disease (AD), underlining the importance of in vitro models of the human BBB with physiological relevance. In this review, recent advances in human BBB-on-a-chip technologies are highlighted and their potential for pathogenesis studies and drug prescreening for AD treatment are discussed.
摘要
血脑屏障 (BBB) 是一种独特的血管结构，作为维持脑内环境稳定的分子转运门户。据报道，慢性破坏或打破 BBB 会导致神经退行性疾病。尽管如此，对人类 BBB 病理生理学和药物开发的研究仍然高度依赖于使用固有不同动物的研究。此外，更多的研究表明，动物模型在模拟阿尔茨海默病 (AD) 方面并不合适，这凸显了具有生理相关性的人 BBB 体外模型在发病机制研究和 AD 治疗药物预筛选中的重要性。在这篇综述中，突出了人 BBB 芯片技术的最新进展，并讨论了它们在发病机制研究和 AD 治疗药物预筛选中的应用潜力。
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