Wong Chee-Wai, Matsumura Saiko, Htoon Hla Myint, Tan Shoun, Tan Colin S, Ang Marcus, Wong Yee-Ling, Agrawal Rupesh, Sabanayagam Charumati, Saw Seang-Mei
Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.
Front Med (Lausanne). 2021 May 17;8:619767. doi: 10.3389/fmed.2021.619767. eCollection 2021.
The risk of pathologic myopia (PM) increases with worsening myopia and may be related to retinal microvasculature alterations. To evaluate this, we analyzed the macular microvasculature of myopes with swept source-optical coherence tomographic angiography (SS-OCTA) in adolescent and young adult Singaporeans. This is a prevalent case-control study including 93 young Chinese from the Strabismus, Amblyopia and Refractive error in Singaporean children (STARS, = 45) study and the Singapore Cohort Study of Risk Factors for Myopia (SCORM, = 48) studies. Macular vessel density (VD) measurements were obtained from 3 × 3 mm SS-OCTA scans and independently assessed using ImageJ. These measurements were compared between individuals with non-high myopia [non-HM, = 40; SE >-5.0 diopter (D)] and HM (SE ≤-5.0D, = 53). The mean macular VD was 40.9 ± 0.6% and 38.2 ± 0.5% in the non-HM and HM, groups, respectively ( = 0.01 adjusted for age and gender). Mean FAZ area in the superficial layer was 0.22 ± 0.02 mm in the HM group, which was smaller compared to non-HM group (0.32 ± 0.03 mm, = 0.04). Mean deep FAZ area was similar between the two groups (0.45 ± 0.03 mm and 0.48 ± 0.04 mm in the HM and non-HM groups, respectively, = 0.70). VD was lower and superficial FAZ area was smaller, in adolescents and young adults with HM compared to non-HM. These findings require validation in prospective studies to assess their impact on the subsequent development of PM.
病理性近视（PM）的风险随着近视程度的加重而增加，并且可能与视网膜微血管改变有关。为了对此进行评估，我们使用扫频光学相干断层扫描血管造影（SS-OCTA）分析了新加坡青少年和年轻成年人近视患者的黄斑微血管情况。这是一项现况病例对照研究，纳入了93名来自新加坡儿童斜视、弱视和屈光不正（STARS，n = 45）研究以及新加坡近视危险因素队列研究（SCORM，n = 48）的年轻华裔。从3×3 mm的SS-OCTA扫描中获取黄斑血管密度（VD）测量值，并使用ImageJ进行独立评估。对非高度近视[非HM，n = 40；等效球镜度（SE）>-5.0屈光度（D）]和高度近视（SE≤-5.0D，n = 53）个体的这些测量值进行比较。非HM组和HM组的平均黄斑VD分别为40.9±0.6%和38.2±0.5%（经年龄和性别校正后P = 0.01）。HM组表层的平均黄斑无血管区（FAZ）面积为0.22±0.02 mm²，与非HM组相比更小（0.32±0.03 mm²，P = 0.04）。两组之间深层FAZ平均面积相似（HM组和非HM组分别为0.45±0.03 mm²和0.48±0.04 mm²，P = 0.70）。与非HM相比，HM的青少年和年轻成年人的VD较低且表层FAZ面积较小。这些发现需要在前瞻性研究中进行验证，以评估它们对PM后续发展的影响。
