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全基因组筛选鉴定出肝癌的预后长非编码 RNA。

Genome-Wide Screening Identifies Prognostic Long Noncoding RNAs in Hepatocellular Carcinoma.

机构信息

Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, China.

出版信息

Biomed Res Int. 2021 May 20;2021:6640652. doi: 10.1155/2021/6640652. eCollection 2021.

DOI:10.1155/2021/6640652
PMID:34095306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8163536/
Abstract

Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. Therefore, there is an urgent call for the investigation of novel biomarkers in HCC. In the present study, we identified 6 upregulated lncRNAs in HCC, including LINC01134, RHPN1-AS1, NRAV, CMB9-22P13.1, MKLN1-AS, and MAPKAPK5-AS1. Higher expression of these lncRNAs was correlated to a more advanced cancer stage and a poorer prognosis in HCC patients. Enrichment analysis revealed that these lncRNAs played a crucial role in HCC progression, possibly through a series of cancer-related biological processes, such as cell cycle, DNA replication, histone acetyltransferase complex, fatty acid oxidation, and lipid modification. Moreover, competing endogenous RNA (ceRNA) network analysis revealed that these lncRNAs could bind to certain miRNAs to promote HCC progression. Loss-of-function assays indicated that silencing of RHPN1-AS1 significantly suppressed HCC proliferation and migration. Though further validations are still needed, these identified lncRNAs could serve as valuable potential biomarkers for HCC prognosis.

摘要

肝细胞癌（HCC）是一种预后较差的常见恶性肿瘤。因此，迫切需要研究 HCC 的新型生物标志物。在本研究中，我们鉴定了 HCC 中 6 个上调的 lncRNA，包括 LINC01134、RHPN1-AS1、NR_040123.1、CMB9-22P13.1、MKLN1-AS 和 MAPKAPK5-AS1。这些 lncRNA 的高表达与 HCC 患者更晚期的癌症分期和更差的预后相关。富集分析表明，这些 lncRNA 在 HCC 进展中发挥关键作用，可能通过一系列与癌症相关的生物学过程，如细胞周期、DNA 复制、组蛋白乙酰转移酶复合物、脂肪酸氧化和脂质修饰。此外，竞争性内源性 RNA（ceRNA）网络分析表明，这些 lncRNA 可以与某些 miRNA 结合，促进 HCC 进展。功能丧失实验表明，沉默 RHPN1-AS1 可显著抑制 HCC 的增殖和迁移。尽管仍需要进一步验证，但这些鉴定的 lncRNA 可作为 HCC 预后有价值的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b683/8163536/8154c46a8d08/BMRI2021-6640652.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b683/8163536/8154c46a8d08/BMRI2021-6640652.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b683/8163536/3c79d1355a81/BMRI2021-6640652.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b683/8163536/5f98fc3a07b8/BMRI2021-6640652.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b683/8163536/7c74d2bed982/BMRI2021-6640652.006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b683/8163536/8154c46a8d08/BMRI2021-6640652.008.jpg

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