Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, China.
Department of Anesthesiology, the First Affiliated Hospital of China Medical University, Shenyang, China.
Curr Pharm Des. 2021;27(26):2934-2942. doi: 10.2174/1381612827666210608150640.
Lung diseases are common clinical illnesses with high morbidity and mortality, which seriously threaten human health. In recent years, increasing evidence suggests that exosomes play a pivotal role in intercellular communication by delivering their cargo to pulmonary target cells, such as microRNAs. Physiologically, exosomes have been shown to be a critical mediator in maintaining homeostasis function in the complex thin-walled lung tissue and airway structure. Apart from being a diagnostic and prognostic biomarker, exosomes also participate in the progression of some lung diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis, acute lung injury, lung cancer, interstitial lung disease, and tuberculosis. Here, we summarize the recent findings on the involvement of exosomes and exosomal microRNAs in the pathogenesis, diagnosis, and therapy of lung diseases, aiming to provide more information to discover novel diagnostic methods and treatment strategies for these disorders.
肺部疾病是常见的临床疾病，具有较高的发病率和死亡率，严重威胁着人类的健康。近年来，越来越多的证据表明，外泌体通过将其 cargo 递送至肺部靶细胞（如 microRNAs），在细胞间通讯中发挥着关键作用。在生理上，外泌体已被证明是维持复杂薄壁肺组织和气道结构中内稳态功能的重要介质。除了作为诊断和预后生物标志物外，外泌体还参与了一些肺部疾病的进展，如慢性阻塞性肺疾病、哮喘、肺纤维化、急性肺损伤、肺癌、间质性肺病和结核病。在这里，我们总结了外泌体和外泌体 microRNAs 在肺部疾病发病机制、诊断和治疗中的最新发现，旨在提供更多的信息，以发现这些疾病的新的诊断方法和治疗策略。
