Santos Marisa, Monteiro Andrea L, Santos Bráulio
Nucleo de Avaliacao de Tecnologias Em Saude, Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil.
Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Health Qual Life Outcomes. 2021 Jun 10;19(1):162. doi: 10.1186/s12955-021-01671-6.
The EQ-5D-3L is a widely used generic health-related quality of life measure commonly applied to describe health outcomes and to measure disease burden. The aim of this study was to generate Brazilian population norms, stratified by age and gender, based on Brazilian preference weights for EQ-5D-3L.
A multicenter cross-sectional study was conducted in three Brazilian urban areas. The final sample consisted of 5774 respondents, aged from 18 to 64 years. Amongst other information, respondents were asked to self-report their health status using the EQ-5D-3L descriptive system and visual analog scale (EQ-VAS). Data on socio-demographic characteristics was obtained through specific questionnaires. The Brazilian TTO scoring algorithm was used to derive the utility values. Multivariate logistic regression models were fitted to analyze the influence of age, sex, education status and sample site on the presence of any problem for each dimension of EQ5D.
Mean values were computed for both weighted index scores and self-rated health status (EQ-VAS), and stratified by gender and age groups. Health status declines with age, ranging between 0.87 for the youngest group 18-29 year-olds and 0.76 for 60-64-year-old. Men reported higher scores (0.85) than the woman (0.79). Lower education levels were associated with lower EQ-5D index score in most age groups.
This study provides EQ-5D reference values for the Brazilian population. These values can be used by local decision-makers and researchers in economic evaluations and population health studies.
EQ-5D-3L是一种广泛使用的通用健康相关生活质量测量工具,常用于描述健康结果和衡量疾病负担。本研究的目的是根据巴西EQ-5D-3L的偏好权重,生成按年龄和性别分层的巴西人群规范。
在巴西三个城市地区进行了一项多中心横断面研究。最终样本包括5774名年龄在18至64岁之间的受访者。除其他信息外,要求受访者使用EQ-5D-3L描述系统和视觉模拟量表(EQ-VAS)自我报告其健康状况。通过特定问卷获取社会人口学特征数据。使用巴西TTO评分算法得出效用值。拟合多变量逻辑回归模型,以分析年龄、性别、教育状况和样本地点对EQ5D各维度存在任何问题的影响。
计算了加权指数得分和自我评估健康状况(EQ-VAS)的平均值,并按性别和年龄组进行分层。健康状况随年龄下降,最年轻的18-29岁组为0.87,60-64岁组为0.76。男性报告的得分(0.85)高于女性(0.79)。在大多数年龄组中,较低的教育水平与较低的EQ-5D指数得分相关。
本研究为巴西人群提供了EQ-5D参考值。当地决策者和研究人员可在经济评估和人群健康研究中使用这些值。