Lee Dong Hyeon, Kim Chae Hyun, Youn Jiman, Jeong Joonsoo
School of Mechanical Engineering, Pusan National University, Pusan, 46241 South Korea.
Department of Biomedical Engineering, Pusan National University, Yangsan, 50612 South Korea.
Biomed Eng Lett. 2021 Apr 15;11(2):97-105. doi: 10.1007/s13534-021-00188-7. eCollection 2021 May.
Long-term reliability of implantable biomedical devices is a critical issue for their practical usefulness and successful translation into clinical application. Reliability is particularly of great concern for recently demonstrated devices based on new materials typically relying on polymeric thin films and microfabrication process. While reliability testing protocol has been well-established for traditional metallic packages, common evaluation methods for polymer-based microdevices has yet to be agreed upon, even though various testing methods have been proposed. This article is aiming to summarize the evaluation methods on long-term reliability of emerging biomedical implants based on polymeric thin-films in terms of their theories and implementation with specific focus on difference from the traditional metallic packages.
可植入生物医学设备的长期可靠性对于其实际效用以及成功转化为临床应用而言是一个关键问题。对于最近展示的基于通常依赖聚合物薄膜和微加工工艺的新材料的设备，可靠性尤其令人担忧。虽然传统金属封装的可靠性测试协议已经确立，但基于聚合物的微型设备的通用评估方法尚未达成共识，尽管已经提出了各种测试方法。本文旨在从理论和实施方面总结基于聚合物薄膜的新型生物医学植入物长期可靠性的评估方法，特别关注与传统金属封装的差异。
