Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, P.O. Box 5163639888, Tabriz, Iran.
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Infection. 2021 Dec;49(6):1133-1147. doi: 10.1007/s15010-021-01644-3. Epub 2021 Jun 23.
The escalating prevalence of coronavirus disease 2019 (COVID-19) worldwide, with an increased rate of morbidity and mortality, highlights an urgent need to develop more effective therapeutic interventions. Despite the authorized treatment against COVID-19 by the European Union (EU), the safety and effectiveness of this therapeutic strategy for a wide variety of patients have remained a significant challenge. In this respect, micronutrients such as vitamins and minerals, as essential factors, can be considered for improving the function of the immune system and accelerating the treatment procedure. Dietary supplements can attenuate vascular and inflammatory manifestations related to infectious diseases in large part due to their anti-inflammatory and antioxidant properties. Recently, it has been revealed that poor nutritional status may be one of the notable risk factors in severe COVID-19 infections. In the current review, we focus on the micronutrient therapy of COVID-19 patients and provide a comprehensive insight into the essential vitamins/minerals and their role in controlling the severity of the COVID-19 infection. We also discuss the recent advancements, challenges, negative and positive outcomes in relevance to this approach.
新型冠状病毒病 (COVID-19) 在全球范围内的发病率不断上升，发病率和死亡率不断增加，这凸显了迫切需要开发更有效的治疗干预措施。尽管欧盟 (EU) 已授权针对 COVID-19 的治疗方法，但对于广泛的患者群体而言，这种治疗策略的安全性和有效性仍然是一个重大挑战。在这方面，作为必需因素的微量营养素，如维生素和矿物质，可以被考虑用于改善免疫系统的功能并加速治疗过程。膳食补充剂在很大程度上可以通过其抗炎和抗氧化特性来减轻与传染病相关的血管和炎症表现。最近，人们发现营养不良可能是重症 COVID-19 感染的显著危险因素之一。在本综述中，我们重点关注 COVID-19 患者的微量营养素治疗，并全面了解基本维生素/矿物质及其在控制 COVID-19 感染严重程度方面的作用。我们还讨论了与这种方法相关的最新进展、挑战、负面和正面结果。
