School of Engineering, RMIT University, Melbourne, Australia.
Functional Materials and Microsystems Research Group, MicroNano Research Facility, RMIT University, Melbourne, Australia.
Nat Commun. 2021 Jun 23;12(1):3897. doi: 10.1038/s41467-021-23278-7.
A major health concern of the 21 century is the rise of multi-drug resistant pathogenic microbial species. Recent technological advancements have led to considerable opportunities for low-dimensional materials (LDMs) as potential next-generation antimicrobials. LDMs have demonstrated antimicrobial behaviour towards a variety of pathogenic bacterial and fungal cells, due to their unique physicochemical properties. This review provides a critical assessment of current LDMs that have exhibited antimicrobial behaviour and their mechanism of action. Future design considerations and constraints in deploying LDMs for antimicrobial applications are discussed. It is envisioned that this review will guide future design parameters for LDM-based antimicrobial applications.
二十一世纪的一个主要健康问题是多药耐药性致病微生物物种的兴起。最近的技术进步为低维材料 (LDMs) 作为潜在的下一代抗菌药物提供了巨大的机会。由于其独特的物理化学性质，LDMs 对各种致病细菌和真菌细胞表现出抗菌行为。本综述对表现出抗菌行为及其作用机制的现有 LDMs 进行了批判性评估。讨论了在抗菌应用中部署 LDMs 的未来设计考虑因素和限制。可以预见，本综述将为基于 LDM 的抗菌应用的未来设计参数提供指导。
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