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具有社会异质性的传染病动力学模型。

Kinetic models for epidemic dynamics with social heterogeneity.

机构信息

Mathematics and Computer Science Department, University of Ferrara, Ferrara, Italy.

Sorbonne Université, CNRS, Université de Paris, Inria Laboratoire Jacques-Louis Lions, 75005, Paris, France.

出版信息

J Math Biol. 2021 Jun 26;83(1):4. doi: 10.1007/s00285-021-01630-1.

Abstract

We introduce a mathematical description of the impact of the number of daily contacts in the spread of infectious diseases by integrating an epidemiological dynamics with a kinetic modeling of population-based contacts. The kinetic description leads to study the evolution over time of Boltzmann-type equations describing the number densities of social contacts of susceptible, infected and recovered individuals, whose proportions are driven by a classical SIR-type compartmental model in epidemiology. Explicit calculations show that the spread of the disease is closely related to moments of the contact distribution. Furthermore, the kinetic model allows to clarify how a selective control can be assumed to achieve a minimal lockdown strategy by only reducing individuals undergoing a very large number of daily contacts. We conduct numerical simulations which confirm the ability of the model to describe different phenomena characteristic of the rapid spread of an epidemic. Motivated by the COVID-19 pandemic, a last part is dedicated to fit numerical solutions of the proposed model with infection data coming from different European countries.

摘要

我们通过将基于人口的接触的动力学模型与流行病学动力学相结合,引入了一种用于描述日常接触次数对传染病传播影响的数学描述。这种动力学描述使得我们可以研究描述易感者、感染者和康复者的社会接触数量密度的玻尔兹曼型方程随时间的演化,其比例由流行病学中的经典 SIR 型房室模型驱动。显式计算表明,疾病的传播与接触分布的矩密切相关。此外,该动力学模型还可以阐明如何通过仅减少经历大量日常接触的个体来假设选择性控制,从而实现最小封锁策略。我们进行了数值模拟,这些模拟证实了该模型能够描述传染病快速传播的不同特征现象。受 COVID-19 大流行的启发,最后一部分专门用于用来自不同欧洲国家的感染数据拟合所提出模型的数值解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ec/8236059/0dfb806ee1ef/285_2021_1630_Fig1_HTML.jpg

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