中国小鼠乳腺肿瘤病毒样病毒相关乳腺癌的患病率及特征
Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China.
作者信息
Wang Fa-Liang, Zhang Xiao-Li, Yang Ming, Lin Jun, Yue Yong-Fang, Li Ya-Dan, Wang Xian, Shu Qiang, Jin Hong-Chuan
机构信息
Department of Surgical Oncology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Binsheng Road 3333, Hangzhou, 310052, China.
Electron Microscope Room, Medical School of Hebei North University, Zhangjiakou, China.
出版信息
Infect Agent Cancer. 2021 Jun 26;16(1):47. doi: 10.1186/s13027-021-00383-2.
BACKGROUND
Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear. Besides, the prevalence of MMTV-LV in women breast cancer tissue varies in different countries and its dependent factors remain inconclusive.
METHODS
In the first part of the study, a case-control study was performed. 119 breast cancer samples (84 from Northern China and 35 from Southern China) and 50 breast fibroadenoma specimens were collected from Chinese women patients. MMTV-like env sequence and the homology to MMTV env gene were analysed by semi-nested polymerase chain reaction (PCR). We also explored the association of MMTV-LV prevalence with sample sources (Southern and Northern China) and patients' clinicopathological characteristics. To investigate the dependent factors of the prevalence of MMTV-LV in breast cancer worldwide, a meta-analysis was conducted in the second part of the study.
RESULTS
We found that the prevalence of MMTV-LV was much higher in breast cancer tissues (17.65%) than that in breast fibroadenoma specimens (4.00%) (P < 0.05). MMTV-LV prevalence in Chinese women breast cancer tissues was significantly different between Southern China (5.71%) and Northern China (22.62%) (P < 0.05). The prevalence of MMTV-LV also associates significantly with expression of HER2, but shows no significant correlation with other parameters. In the meta-analysis, we found that MMTV-LV prevalence in breast cancer tissue was dependent on the distribution of M. domesticus mouse (M. d), M. musculus mouse (M.m) and M.castaneus mouse (M.c) worldwide (P < 0.05).
CONCLUSION
The distribution of house mice may be a crucial environmental factor that explains the geographic differences in human breast cancer incidence. Our findings may provide a potential avenue of prevention, diagnosis and treatment for breast cancer.
背景
尽管进行了广泛的分子流行病学研究，但中国女性乳腺癌中鼠乳腺肿瘤病毒样病毒（MMTV-LV）的流行情况和特征仍不清楚。此外，MMTV-LV在女性乳腺癌组织中的流行率在不同国家有所不同，其相关因素尚无定论。
方法
在研究的第一部分，进行了一项病例对照研究。从中国女性患者中收集了119份乳腺癌样本（84份来自中国北方，35份来自中国南方）和50份乳腺纤维瘤标本。通过半巢式聚合酶链反应（PCR）分析MMTV样env序列及其与MMTV env基因的同源性。我们还探讨了MMTV-LV流行率与样本来源（中国南方和北方）以及患者临床病理特征之间的关联。为了研究全球乳腺癌中MMTV-LV流行率的相关因素，在研究的第二部分进行了一项荟萃分析。
结果
我们发现MMTV-LV在乳腺癌组织中的流行率（17.65%）远高于乳腺纤维瘤标本（4.00%）（P < 0.05）。中国女性乳腺癌组织中MMTV-LV的流行率在中国南方（5.71%）和北方（22.62%）之间存在显著差异（P < 0.05）。MMTV-LV的流行率也与HER2的表达显著相关，但与其他参数无显著相关性。在荟萃分析中，我们发现乳腺癌组织中MMTV-LV的流行率取决于全球小家鼠（M. d）、小家鼠（M.m）和栗色小鼠（M.c）的分布（P < 0.05）。
结论
家鼠的分布可能是解释人类乳腺癌发病率地理差异的关键环境因素。我们的研究结果可能为乳腺癌的预防、诊断和治疗提供一条潜在途径。
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