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聚丁二酸丁二醇酯人工支架促进周围神经再生。

Polybutylene succinate artificial scaffold for peripheral nerve regeneration.

机构信息

Centro Mediterraneo Ricerca e Training (Ce.Me.Ri.T), Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.

Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Palermo, Italy.

出版信息

J Biomed Mater Res B Appl Biomater. 2022 Jan;110(1):125-134. doi: 10.1002/jbm.b.34896. Epub 2021 Jun 27.

DOI:10.1002/jbm.b.34896
PMID:34180135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9290626/
Abstract

Regeneration and recovery of nerve tissues are a great challenge for medicine, and positively affect the quality of life of patients. The development of tissue engineering offers a new approach to the problem with the creation of multifunctional artificial scaffolds that act on various levels in the damaged tissue, providing physical and biochemical support for the growth of nerve cells. In this study, the effects of the use of a tubular scaffold made of polybutylene succinate (PBS), surgically positioned at the level of a sciatic nerve injured in rat, between the proximal stump and the distal one, was investigated. Scaffolds characterization was carried out by scanning electron microscopy and X-ray microcomputed tomography and magnetic resonance imaging, in vivo. The demonstration of the nerve regeneration was based on the evaluation of electroneurography, measuring the weight of gastrocnemius and tibialis anterior muscles, histological examination of regenerated nerves and observing the recovery of the locomotor activity of animals. The PBS tubular scaffold minimized iatrogenic trauma on the nerve, acting as a directional guide for the regenerating fibers by conveying them toward the distal stump. In this context, neurotrophic and neurotropic factors may accumulate and perform their functions, while invasion by macrophages and scar tissue is hampered.

摘要

神经组织的再生和恢复是医学的一大挑战，它会显著影响患者的生活质量。组织工程的发展为解决这一问题提供了一种新方法，即创建多功能人工支架，在受损组织的各个层面发挥作用，为神经细胞的生长提供物理和生化支持。在这项研究中，研究了将聚丁二酸丁二醇酯（PBS）制成的管状支架在大鼠坐骨神经损伤部位的近端残端和远端残端之间进行手术放置的效果。通过扫描电子显微镜、X 射线微计算机断层扫描和磁共振成像对支架进行了体内特性分析。神经再生的证明是基于电神经图的评估，测量比目鱼肌和胫骨前肌的重量，对再生神经进行组织学检查，并观察动物运动活动的恢复情况。PBS 管状支架最大限度地减少了对神经的医源性损伤，通过将再生纤维引导到远端残端，起到定向引导纤维的作用。在这种情况下，神经营养和神经营养因子可能会积聚并发挥作用，同时阻止巨噬细胞和瘢痕组织的侵入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/6d1c0d01cdca/JBM-110-125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/c1b57b83af9d/JBM-110-125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/62b5217986d7/JBM-110-125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/503e94e8aeb7/JBM-110-125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/5ecc6b12e239/JBM-110-125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/6d1c0d01cdca/JBM-110-125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/c1b57b83af9d/JBM-110-125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/62b5217986d7/JBM-110-125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/503e94e8aeb7/JBM-110-125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/5ecc6b12e239/JBM-110-125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e885/9290626/6d1c0d01cdca/JBM-110-125-g003.jpg

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