Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Querrey Simpson Institute for Biotechnology, Northwestern University, Evanston, IL, USA.
Nat Biotechnol. 2021 Oct;39(10):1228-1238. doi: 10.1038/s41587-021-00948-x. Epub 2021 Jun 28.
Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.
在外科手术恢复期，需要使用临时心脏起搏器，这些起搏器包括经皮导联和外置硬件，存在感染风险，限制了患者的活动能力，并且在导联移除时可能会损伤心脏。在这里，我们报告了一种无导线、无电池、完全可植入的心脏起搏器，用于术后控制心率和节律，在经过规定的工作时间后，它可以通过自然的生物过程完全溶解和清除。我们展示了这些设备在小鼠、大鼠、兔子、犬和人类心脏模型中，针对不同大小的心脏提供了有效的起搏，其具有定制的几何形状和操作时间尺度，由无线能量传输提供动力。这种方法克服了传统临时起搏设备的关键缺点，可能成为下一代术后临时起搏技术的基础。
