Ferrante Margherita, Cristaldi Antonio, Oliveri Conti Gea
Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy.
Catania, Messina, Enna Cancer Registry, Via S. Sofia 87, 95123 Catania, Italy.
J Pers Med. 2021 Jun 2;11(6):500. doi: 10.3390/jpm11060500.
The daily environmental exposure of humans to plasticizers may adversely affect human health, representing a global issue. The altered expression of microRNAs (miRNAs) plays an important pathogenic role in exposure to plasticizers. This systematic review summarizes recent findings showing the modified expression of miRNAs in cancer due to exposure to plasticizers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the literature published in the past 10 years, focusing on the relationship between plasticizer exposure and the expression of miRNAs related to cancer. Starting with 535 records, 17 articles were included. The results support the hypothesis that exposure to plasticizers causes changes in or the deregulation of a number of oncogenic miRNAs and show that the interaction of plasticizers with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22, miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a, and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolic changes that participate in many overlapping cellular processes, and the evaluation of miRNA-level changes can be a useful target for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers.
人类日常环境中接触增塑剂可能会对人类健康产生不利影响，这是一个全球性问题。微小RNA（miRNA）表达的改变在接触增塑剂过程中起着重要的致病作用。本系统综述总结了近期的研究结果，这些结果表明由于接触增塑剂，癌症中miRNA的表达发生了改变。按照系统评价和Meta分析的首选报告项目（PRISMA）方法，我们对过去10年发表的文献进行了系统综述，重点关注增塑剂暴露与癌症相关miRNA表达之间的关系。从535条记录开始，纳入了17篇文章。结果支持这样的假设，即接触增塑剂会导致许多致癌miRNA发生变化或失调，并表明增塑剂与一些冗余miRNA（如let-7f、let-7g、miR-125b、miR-134、miR-146a、miR-22、miR-192、miR-222、miR-26a、miR-26b、miR-27b、miR-296、miR-324、miR-335、miR-122、miR-23b、miR-200、miR-29a和miR-21）的相互作用可能会引发深度改变。这些遗传毒性和致癌反应最终可能导致异常的细胞信号通路和代谢变化，这些变化参与许多重叠的细胞过程，而对miRNA水平变化的评估可能是环境污染物（包括塑料添加剂和增塑剂）毒理学评估的一个有用靶点。
