Koussiouris John, Looby Nikita, Anderson Melanie, Kulasingam Vathany, Chandran Vinod
Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5T 0S8, Canada.
Metabolites. 2021 Jun 10;11(6):375. doi: 10.3390/metabo11060375.
Metabolomics investigates a broad range of small molecules, allowing researchers to understand disease-related changes downstream of the genome and proteome in response to external environmental stimuli. It is an emerging technology that holds promise in identifying biomarkers and informing the practice of precision medicine. In this review, we summarize the studies that have examined endogenous metabolites in patients with psoriasis and/or psoriatic arthritis using nuclear magnetic resonance (NMR) or mass spectrometry (MS) and were published through 26 January 2021. A standardized protocol was used for extracting data from full-text articles identified by searching OVID Medline ALL, OVID Embase, OVID Cochrane Central Register of Controlled Trials and BIOSIS Citation Index in Web of Science. Thirty-two studies were identified, investigating various sample matrices and employing a wide variety of methods for each step of the metabolomics workflow. The vast majority of studies identified metabolites, mostly amino acids and lipids that may be associated with psoriasis diagnosis and activity. Further exploration is needed to identify and validate metabolomic biomarkers that can accurately and reliably predict which psoriasis patients will develop psoriatic arthritis, differentiate psoriatic arthritis patients from patients with other inflammatory arthritides and measure psoriatic arthritis activity.
代谢组学研究范围广泛的小分子，使研究人员能够了解基因组和蛋白质组下游因外部环境刺激而产生的与疾病相关的变化。它是一项新兴技术，在识别生物标志物和为精准医疗实践提供信息方面具有前景。在本综述中，我们总结了截至2021年1月26日发表的、使用核磁共振（NMR）或质谱（MS）检测银屑病和/或银屑病关节炎患者内源性代谢物的研究。采用标准化方案从通过检索OVID Medline ALL、OVID Embase、OVID Cochrane对照试验中心注册库和Web of Science中的BIOSIS引文索引所确定的全文文章中提取数据。共确定了32项研究，这些研究调查了各种样本基质，并在代谢组学工作流程的每个步骤中采用了多种方法。绝大多数研究都鉴定出了代谢物，其中大多是可能与银屑病诊断和活动相关的氨基酸和脂质。需要进一步探索以识别和验证能够准确可靠地预测哪些银屑病患者会发展为银屑病关节炎、区分银屑病关节炎患者与其他炎性关节炎患者以及测量银屑病关节炎活动度的代谢组学生物标志物。
