Li Dan, Zhang Xi, Chen Xiao, Li Wei
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Department of Burn Surgery, The First Hospital of Jilin University, Changchun, China.
Front Bioeng Biotechnol. 2022 Feb 11;10:850366. doi: 10.3389/fbioe.2022.850366. eCollection 2022.
Polymeric vesicles served as the most promising candidates of drug delivery nanocarriers are attracting increasing attention in cancer therapy. Significant advantages have been reported, including hydrophilic molecules with high loading capacity, controllable drug release, rapid and smart responses to stimuli and versatile functionalities. In this study, we have made a systematic review of all aspects of nano-vesicles as drug delivery vectors for cancer treatment, mainly including the following aspect: characteristics of polymeric nanovesicles, polymeric nanovesicle synthesis, and recent progress in applying polymeric nanovesicles in antitumor drug delivery. Polymer nanovesicles have the advantages of synergistic photothermal and imaging in improving the anticancer effect. Therefore, we believe that drug carrier of polymer nanovesicles is a key direction for cancer treatment.
作为最有前途的药物递送纳米载体候选物的聚合物囊泡在癌症治疗中受到越来越多的关注。已报道了其显著优势，包括对亲水分子的高负载能力、可控的药物释放、对刺激的快速智能响应以及多功能性。在本研究中，我们对纳米囊泡作为癌症治疗药物递送载体的各个方面进行了系统综述，主要包括以下方面：聚合物纳米囊泡的特性、聚合物纳米囊泡的合成以及聚合物纳米囊泡在抗肿瘤药物递送中的最新进展。聚合物纳米囊泡在提高抗癌效果方面具有协同光热和成像的优势。因此，我们认为聚合物纳米囊泡药物载体是癌症治疗的一个关键方向。
