Shirpoor Minoo, Tofighi Asghar, Shirpoor Alireza, Pourjabali Masoumeh, Chodari Leila
Department of Exercise Physiology and Corrective Movements, Faculty of Sport Sciences, Urmia University, Urmia, I.R. Iran.
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, I.R. Iran.
Res Pharm Sci. 2021 May 12;16(3):294-304. doi: 10.4103/1735-5362.314828. eCollection 2021 Jun.
The specific molecular mediators involved in dyslipidemia in older people are not yet clearly understood. The current study was, thus, an attempt to investigate whether moderate aerobic exercises and curcumin administration alleviates the abnormalities caused by aging in the rats' liver.
Thirty-two eight-year-old young rats were classified into five groups, namely, young control, aged control, aged-curcumin, aged-exercise, and aged-curcumin-exercise co-treatment. The rats in the exercise groups were trained on an animal treadmill for 60 min/day five times per week for eight weeks.
FINDINGS/RESULTS: The results revealed a significant increase in FAT/CD36, PTP1B, significantly decreased HNF4α genes expression, increase in LDL and cholesterol in the aged group compared to the young control. Compared to those in the young control group, no significant changes in HDL and TG amounts in the aged control were observed. Moreover, compared to the young control, the aged group showed liver histological changes such as fibrosis and mild or grade 1 steatohepatitis. Moderate aerobic exercise and curcumin alone or in combination completely masked this effect.
The findings revealed dyslipidemia and liver steatosis related to aging might be partly associated with changes in hepatic transcriptional factors which can be mitigated moderate aerobic exercise and curcumin.
老年人血脂异常所涉及的具体分子介质尚未完全明确。因此，本研究旨在探讨适度有氧运动和姜黄素给药是否能减轻大鼠肝脏衰老引起的异常。
将32只8岁的年轻大鼠分为五组，即年轻对照组、老年对照组、老年姜黄素组、老年运动组和老年姜黄素 - 运动联合治疗组。运动组的大鼠在动物跑步机上进行训练，每天60分钟，每周5次，持续8周。
结果显示，与年轻对照组相比，老年组中FAT/CD36、PTP1B显著增加，HNF4α基因表达显著降低，低密度脂蛋白和胆固醇增加。与年轻对照组相比，老年对照组中高密度脂蛋白和甘油三酯含量无显著变化。此外，与年轻对照组相比，老年组出现肝脏组织学变化，如纤维化和轻度或1级脂肪性肝炎。适度有氧运动和姜黄素单独或联合使用完全掩盖了这种影响。
研究结果表明，与衰老相关的血脂异常和肝脏脂肪变性可能部分与肝脏转录因子的变化有关，适度有氧运动和姜黄素可减轻这些变化。
