School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
Centre for Drug Discovery and Molecular Pharmacology (CDDMP), Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
F1000Res. 2021 Jun 7;10:451. doi: 10.12688/f1000research.52528.1. eCollection 2021.
A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues. Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds. Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost. However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing. Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment. The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers. The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%). The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment. In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility. The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%. The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m /day, 1237g/m day and 1112 g/m /day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis. An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
由于糖尿病导致慢性伤口的患病率急剧上升，这给全球医疗保健和经济带来了严重问题。因此，迫切需要开发一种有效且经济实惠的慢性伤口敷料。最近的研究表明，由于其安全性和相对较低的成本，生物活性化合物没食子酸（GA）在伤口恢复方面具有潜在的应用前景。然而，目前针对将 GA 制成稳定且功能齐全的水胶体薄膜敷料的研究还很少。因此，本研究旨在制备和表征载 GA 的海藻酸钠基水胶体薄膜敷料，该敷料有望用作低至中度化脓性慢性伤口的治疗。水胶体复合膜通过将海藻酸钠（SA）与不同组合的聚合物混合预先配制成型。水胶体膜是通过溶剂浇铸法制备的，最令人满意的膜配方进一步与各种 GA 浓度（0.1%、0.5%和 1%）结合。然后对载药膜进行理化性质的表征，以评估其作为慢性伤口治疗的药物传递系统的潜力。在预配方研究中，发现基于海藻酸钠-果胶（SA-PC）的水胶体膜是最令人满意的，因为它具有均一性并且在表面上保持光滑度，同时具有令人满意的膜柔韧性。选择 SA-PC 膜进一步负载 0.1%、0.5%和 1%的 GA。特性研究表明，所有载 GA 的薄膜都具有优越的伤口敷料性能，呈酸性 pH 值范围（3.97-4.04），中等粘度（1600 mPa-s-3198 mPa-s），最佳的水分蒸发传输速率（1195 g/m /天、1237g/m 天和 1112 g/m /天），较慢的水分吸收和薄膜膨胀速度，并且在 FTIR 分析中 GA 和聚合物之间没有化学相互作用。成功开发了一种载有没食子酸的 SA-PC 水胶体敷料，有望成为低至中度化脓性慢性伤口的应用敷料。
