Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Children's Hospital, Pediatric Research Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
EBioMedicine. 2021 Jul;69:103475. doi: 10.1016/j.ebiom.2021.103475. Epub 2021 Jul 10.
The colonisation and development of the gut microbiota has been implicated in paediatric metabolic disorders via its powerful effect on host metabolic and immune homeostasis. Here we summarise the evidence from human studies on the early gut microbiota and paediatric overweight and obesity. Manipulation of the early gut microbiota may represent a promising target for countering the burgeoning metabolic disorders in the paediatric population, provided the assembly patterns of microbiota and their health consequences can be decoded. Therefore, in this review, we pay particular attention to the important ecological drivers affecting the community dynamics of the early gut microbiota. We then discuss the knowledge gaps in commonly studied exposures linking the gut microbiota to metabolic disorders, especially regarding maternal factors and antibiotic use. This review also attempts to give directions for future studies aiming to identify predictive and corrective measures for paediatric metabolic disorders based on the gut microbiota. Gut microbiota; Metabolism; Paediatric overweight and obesity; Ecological driver; Dynamics; Infants.
肠道微生物群的定植和发展通过其对宿主代谢和免疫稳态的强大影响，被认为与儿科代谢紊乱有关。在这里，我们总结了关于早期肠道微生物群与儿科超重和肥胖的人类研究证据。操纵早期肠道微生物群可能代表着对抗儿科人群中不断增加的代谢紊乱的有希望的目标，只要能够解码微生物群的组装模式及其对健康的影响。因此，在这篇综述中，我们特别关注影响早期肠道微生物群群落动态的重要生态驱动因素。然后，我们讨论了将肠道微生物群与代谢紊乱联系起来的常见研究暴露因素中的知识差距，特别是关于母体因素和抗生素使用的知识差距。本综述还试图为未来的研究指明方向，以期根据肠道微生物群来确定儿科代谢紊乱的预测和纠正措施。肠道微生物群；代谢；儿科超重和肥胖；生态驱动因素；动态；婴儿。
