Page-Thomas D P, Bard D, King B, Dingle J T
Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.
Ann Rheum Dis. 1987 Dec;46(12):934-7. doi: 10.1136/ard.46.12.934.
The rate of loss from the synovial cavity of proteoglycan subunit, a major constituent of cartilage, has been measured in rabbits with and without experimental arthritis. The effect of aggregation between proteoglycan and hyaluronic acid upon the rate of elimination has also been investigated. The results indicate that proteoglycan subunit has a clearance half life of around 12 hours in normal joints and that this rate is not significantly altered in the presence of an active synovitis. Neither injection of proteoglycan as an aggregate, nor in a form incapable of aggregation, had any significant effect on clearance rates. These data indicate that loss of proteoglycan from the joint is not retarded by its ability to aggregate with hyaluronic acid in the synovial fluid and, together with measurements of synovial fluid proteoglycan, may enable rates of cartilage breakdown in vivo to be calculated.
在患有和未患有实验性关节炎的兔子中，已对蛋白聚糖亚基（软骨的主要成分）从滑膜腔的流失速率进行了测量。还研究了蛋白聚糖与透明质酸之间的聚集对清除速率的影响。结果表明，蛋白聚糖亚基在正常关节中的清除半衰期约为12小时，并且在存在活动性滑膜炎的情况下，该速率没有明显改变。注射聚集形式的蛋白聚糖或不能聚集的形式，对清除率均无显著影响。这些数据表明，关节中蛋白聚糖的流失不会因其与滑液中透明质酸聚集的能力而受到阻碍，并且与滑液蛋白聚糖的测量结果一起，可能有助于计算体内软骨分解的速率。
