• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于高通量测序的口腔鳞状细胞癌中SUMO化修饰调节因子的表达及预后分析

Expression and Prognosis Analysis of SUMOylation Regulators in Oral Squamous Cell Carcinoma Based on High-Throughput Sequencing.

作者信息

Meng Yutong, Li Xiaozhi

机构信息

Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang, China.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.

出版信息

Front Genet. 2021 Jun 29;12:671392. doi: 10.3389/fgene.2021.671392. eCollection 2021.

DOI:10.3389/fgene.2021.671392
PMID:34267779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8277238/
Abstract

INTRODUCTION

Oral squamous cell carcinoma (OSCC) originates from oral mucosal epithelial cells, accounting for more than 90% of oral cancers. The relationship between the expression and prognostic role of SUMOylation regulators in OSCC is rarely studied.

MATERIALS AND METHODS

The expression and survival data of OSCC were derived from TCGA and GEO databases. Wilcoxon test was used to determine the differential expression of the SUMOylation regulators. A prognostic model based on SUMOylation regulator-related genes was constructed by Cox regression. Gene set enrichment analysis was applied to predict the potential biological functions that the genes might be involved in.

RESULTS

RANBP2 and SENP6 had the highest SNV frequency. Eleven genes including PIAS3, RANBP2, USPL1, SENP6, SENP2, SENP5, SAE1, UBA2, PIAS4, UBE2I, and SENP3 were highly expressed in OSCC. The prognostic model based on nine SUMOylation-regulated genes (TRIM37, UFM1, FUBP1, CCNT1, FXR1, HMG20A, RANBP3, SPATA5, and DDX23) had a strong ability to predict the prognosis of OSCC.

CONCLUSION

This study might provide targets for prognostic evaluation and targeted therapy of patients with OSCC.

摘要

引言

口腔鳞状细胞癌（OSCC）起源于口腔黏膜上皮细胞，占口腔癌的90%以上。SUMO化调节剂在OSCC中的表达与预后作用之间的关系鲜有研究。

材料与方法

OSCC的表达及生存数据来自TCGA和GEO数据库。采用Wilcoxon检验确定SUMO化调节剂的差异表达。通过Cox回归构建基于SUMO化调节剂相关基因的预后模型。应用基因集富集分析预测基因可能参与的潜在生物学功能。

结果

RANBP2和SENP6的单核苷酸变异（SNV）频率最高。PIAS3、RANBP2、USPL1、SENP6、SENP2、SENP5、SAE1、UBA2、PIAS4、UBE2I和SENP3这11个基因在OSCC中高表达。基于9个SUMO化调节基因（TRIM37、UFM1、FUBP1、CCNT1、FXR1、HMG20A、RANBP3、SPATA5和DDX23）的预后模型对OSCC患者的预后具有较强的预测能力。

结论

本研究可能为OSCC患者的预后评估和靶向治疗提供靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/53ebb69a4391/fgene-12-671392-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/fa1cdcd58d80/fgene-12-671392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/4a7bd3c32f70/fgene-12-671392-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/683ca64c1dcd/fgene-12-671392-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/9d9af91cb4bc/fgene-12-671392-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/c7e720e0fb76/fgene-12-671392-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/ab3246160b44/fgene-12-671392-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/53ebb69a4391/fgene-12-671392-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/fa1cdcd58d80/fgene-12-671392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/4a7bd3c32f70/fgene-12-671392-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/683ca64c1dcd/fgene-12-671392-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/9d9af91cb4bc/fgene-12-671392-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/c7e720e0fb76/fgene-12-671392-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/ab3246160b44/fgene-12-671392-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6411/8277238/53ebb69a4391/fgene-12-671392-g007.jpg

相似文献

1
Expression and Prognosis Analysis of SUMOylation Regulators in Oral Squamous Cell Carcinoma Based on High-Throughput Sequencing.基于高通量测序的口腔鳞状细胞癌中SUMO化修饰调节因子的表达及预后分析
Front Genet. 2021 Jun 29;12:671392. doi: 10.3389/fgene.2021.671392. eCollection 2021.
2
SUMOylation Regulator-Related Molecules Can Be Used as Prognostic Biomarkers for Glioblastoma.SUMO化调节剂相关分子可作为胶质母细胞瘤的预后生物标志物。
Front Cell Dev Biol. 2021 Apr 9;9:658856. doi: 10.3389/fcell.2021.658856. eCollection 2021.
3
Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics.基于 RNA 测序和生物信息学的口腔鳞状细胞癌基因预后特征的鉴定。
Biomed Res Int. 2021 Apr 1;2021:6657767. doi: 10.1155/2021/6657767. eCollection 2021.
4
Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis.口腔鳞状细胞癌的预后生物标志物和治疗靶点：基于跨数据库分析的研究。
Hereditas. 2021 Apr 23;158(1):15. doi: 10.1186/s41065-021-00181-1.
5
Construction of a SUMOylation regulator-based prognostic model in low-grade glioma.基于 SUMOylation 调节剂的低级别胶质瘤预后模型的构建。
J Cell Mol Med. 2021 Jun;25(12):5434-5442. doi: 10.1111/jcmm.16553. Epub 2021 May 5.
6
Development and Validation of Autophagy-Related Gene Signature and Nomogram for Predicting Survival in Oral Squamous Cell Carcinoma.用于预测口腔鳞状细胞癌生存的自噬相关基因特征及列线图的开发与验证
Front Oncol. 2020 Oct 16;10:558596. doi: 10.3389/fonc.2020.558596. eCollection 2020.
7
[MicroRNA model that can predict the prognosis of oral squamous cell carcinoma based on bioinformatics analysis].基于生物信息学分析的可预测口腔鳞状细胞癌预后的微小RNA模型
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Dec 1;38(6):622-627. doi: 10.7518/hxkq.2020.06.003.
8
A 3-mRNA-based prognostic signature of survival in oral squamous cell carcinoma.一种基于3种mRNA的口腔鳞状细胞癌生存预后特征。
PeerJ. 2019 Jul 31;7:e7360. doi: 10.7717/peerj.7360. eCollection 2019.
9
Identification of novel prognostic indicators for oral squamous cell carcinoma based on proteomics and metabolomics.基于蛋白质组学和代谢组学的口腔鳞状细胞癌新预后指标的鉴定
Transl Oncol. 2023 Jul;33:101672. doi: 10.1016/j.tranon.2023.101672. Epub 2023 Apr 20.
10
Analysis of the Differential Expression Patterns of Sumoylation Enzymes E1, E2 and E3 in Ocular Cell Lines.分析 SUMO 化酶 E1、E2 和 E3 在眼细胞系中的差异表达模式。
Curr Mol Med. 2018;18(8):509-515. doi: 10.2174/1566524019666190112143636.

引用本文的文献

1
Nuclear pore complex protein RANBP2 and related SUMOylation in solid malignancies.核孔复合体蛋白RANBP2及相关的SUMO化修饰在实体恶性肿瘤中的作用
Genes Dis. 2024 Sep 4;12(4):101407. doi: 10.1016/j.gendis.2024.101407. eCollection 2025 Jul.
2
Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中组蛋白翻译后修饰的研究进展。
Clin Epigenetics. 2024 Nov 21;16(1):165. doi: 10.1186/s13148-024-01785-w.
3
Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint.

本文引用的文献

1
SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.SUMO 介导的转录因子调控作为植物将环境线索转导为细胞信号的机制。
Cell Mol Life Sci. 2021 Mar;78(6):2641-2664. doi: 10.1007/s00018-020-03723-4. Epub 2021 Jan 16.
2
Targeting SUMO Signaling to Wrestle Cancer.靶向 SUMO 信号以攻克癌症。
Trends Cancer. 2021 Jun;7(6):496-510. doi: 10.1016/j.trecan.2020.11.009. Epub 2020 Dec 20.
3
SUMO: From Bench to Bedside.SUMO：从基础到临床。
Sumo 调节 SENP2 控制着稳态鳞状细胞有丝分裂-分化检查点。
Cell Death Dis. 2024 Aug 16;15(8):596. doi: 10.1038/s41419-024-06969-z.
4
SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation.SENP5 通过 H2AZ 去 SUMOylation 促进结直肠癌细胞中同源重组介导的 DNA 损伤修复。
J Exp Clin Cancer Res. 2023 Sep 8;42(1):234. doi: 10.1186/s13046-023-02789-9.
5
HMG20A was identified as a key enhancer driver associated with DNA damage repair in oral squamous cell carcinomas.HMG20A 被鉴定为与口腔鳞状细胞癌中 DNA 损伤修复相关的关键增强子驱动因子。
BMC Oral Health. 2022 Nov 5;22(1):473. doi: 10.1186/s12903-022-02500-y.
6
Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth.聚焦降解组的RNA干扰筛选以鉴定对乳腺癌细胞生长重要的蛋白酶。
Front Oncol. 2022 Oct 12;12:960109. doi: 10.3389/fonc.2022.960109. eCollection 2022.
7
Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma.骨骼肌及相关蛋白表达作为胸腺鳞状细胞癌的预后因素
J Thorac Dis. 2022 Sep;14(9):3245-3254. doi: 10.21037/jtd-22-385.
8
HMG20A Inhibit Adipogenesis by Transcriptional and Epigenetic Regulation of MEF2C Expression.HMG20A 通过 MEF2C 表达的转录和表观遗传调控抑制脂肪生成。
Int J Mol Sci. 2022 Sep 12;23(18):10559. doi: 10.3390/ijms231810559.
9
Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases.癌症相关的 SUMO 调节因子失调：蛋白酶和连接酶。
Int J Mol Sci. 2022 Jul 20;23(14):8012. doi: 10.3390/ijms23148012.
10
Identification of Key Proteins from the Alternative Lengthening of Telomeres-Associated Promyelocytic Leukemia Nuclear Bodies Pathway.从端粒替代延长相关早幼粒细胞白血病核体途径中鉴定关键蛋白
Biology (Basel). 2022 Jan 25;11(2):185. doi: 10.3390/biology11020185.
Physiol Rev. 2020 Oct 1;100(4):1599-1619. doi: 10.1152/physrev.00025.2019.
4
Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials.靶向口腔癌中的 AKT/mTOR：机制与临床试验进展。
Int J Mol Sci. 2020 May 6;21(9):3285. doi: 10.3390/ijms21093285.
5
Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts.SUMO 化修饰：机制、病理学和新兴概念，迎来 25 周年纪念。
FEBS J. 2020 Aug;287(15):3110-3140. doi: 10.1111/febs.15319. Epub 2020 May 1.
6
Intricate SUMO-based control of the homologous recombination machinery.基于 SUMO 的同源重组机制的复杂调控。
Genes Dev. 2019 Oct 1;33(19-20):1346-1354. doi: 10.1101/gad.328534.119.
7
SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways.SAE1 通过激活 AKT SUMOylation 介导的信号通路促进人胶质瘤的进展。
Cell Commun Signal. 2019 Jul 25;17(1):82. doi: 10.1186/s12964-019-0392-9.
8
Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.Akt 在口腔鳞状细胞癌中的异构体特异性作用。
Biomolecules. 2019 Jun 27;9(7):253. doi: 10.3390/biom9070253.
9
Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation.沉默 Ubc9 表达通过调节连接蛋白 43 SUMO 化抑制骨肉瘤发生并增强 HSV-TK/GCV 化疗敏感性。
Int J Oncol. 2018 Sep;53(3):1323-1331. doi: 10.3892/ijo.2018.4448. Epub 2018 Jun 21.
10
Knockdown of Uba2 inhibits colorectal cancer cell invasion and migration through downregulation of the Wnt/β-catenin signaling pathway.Uba2基因敲低通过下调Wnt/β-连环蛋白信号通路抑制结肠癌细胞的侵袭和迁移。
J Cell Biochem. 2018 Aug;119(8):6914-6925. doi: 10.1002/jcb.26890. Epub 2018 May 10.