Department of Pediatrics, UCLA Mattel Children's Hospital, University of California at Los Angeles, Los Angeles, CA, United States of America.
Dornsife College of Letters Arts and Sciences Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States of America.
Prev Med. 2021 Dec;153:106727. doi: 10.1016/j.ypmed.2021.106727. Epub 2021 Jul 16.
High acceptance of coronavirus disease 2019 (COVID-19) vaccines is instrumental to ending the pandemic. Vaccine acceptance by subgroups of the population depends on their trust in COVID-19 vaccines. We surveyed a probability-based internet panel of 7832 adults from December 23, 2020-January 19, 2021 about their likelihood of getting a COVID-19 vaccine and the following domains of trust: an individual's generalized trust, trust in COVID-19 vaccine's efficacy and safety, trust in the governmental approval process and general vaccine development process for COVID-19 vaccines, trust in their physician about COVID-19, and trust in other sources about COVID-19. We included identified at-risk subgroups: healthcare workers, older adults (65-74-year-olds and ≥ 75-year-olds), frontline essential workers, other essential workers, and individuals with high-risk chronic conditions. Of 5979 respondents, only 57.4% said they were very likely or somewhat likely to get a COVID-19 vaccine. More hesitant respondents (p < 0.05) included: women, young adults (18-49 years), Blacks, individuals with lower education, those with lower income, and individuals without high-risk chronic conditions. Lack of trust in the vaccine approval and development processes explained most of the demographic variation in stated vaccination likelihood, while other domains of trust explained less variation. We conclude that hesitancy for COVID-19 vaccines is high overall and among at-risk subgroups, and hesitancy is strongly tied to trust in the vaccine approval and development processes. Building trust is critical to ending the pandemic.
新冠病毒疾病 2019（COVID-19）疫苗的高接受度对于结束大流行至关重要。疫苗在人口亚组中的接受程度取决于他们对 COVID-19 疫苗的信任。我们在 2020 年 12 月 23 日至 2021 年 1 月 19 日期间对一个基于概率的互联网成年人小组进行了调查，询问他们接种 COVID-19 疫苗的可能性以及以下信任领域：个人的普遍信任、对 COVID-19 疫苗功效和安全性的信任、对 COVID-19 疫苗的政府批准过程和一般疫苗开发过程的信任、对他们的医生关于 COVID-19 的信任以及对其他关于 COVID-19 的来源的信任。我们包括了确定的高危亚组：医护人员、老年人（65-74 岁和≥75 岁）、一线基本工作人员、其他基本工作人员以及患有高危慢性疾病的个体。在 5979 名受访者中，只有 57.4%表示他们非常有可能或有些可能接种 COVID-19 疫苗。更犹豫不决的受访者（p<0.05）包括：女性、年轻人（18-49 岁）、黑人、受教育程度较低的人、收入较低的人以及没有高危慢性疾病的人。对疫苗批准和开发过程缺乏信任解释了疫苗接种意愿的大部分人口统计学差异，而其他信任领域则解释了较少的差异。我们的结论是，总体而言，对 COVID-19 疫苗的犹豫情绪很高，而且在高危亚组中也是如此，而且犹豫情绪与对疫苗批准和开发过程的信任密切相关。建立信任对于结束大流行至关重要。
