Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Université de Nantes, CNRS, CEISAM UMR6230, Nantes F-44000, France.
Chem Commun (Camb). 2021 Aug 12;57(65):8035-8038. doi: 10.1039/d1cc03079e.
We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.
我们表明，通过结合用于 D-DNP 的优化转移设置以及基于时空编码的超快 2D NMR 实验，可以为溶解动态核极化（D-DNP）增强的底物混合物获得 TOCSY 和多量子（MQ）2D NMR 谱。TOCSY 和 MQ 实验特别适合于混合物分析，这种方法为 NMR 的分析应用（例如鉴定和代谢组学）开辟了显著提高灵敏度的途径。
