Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Institute of Microscale Optoelectronics, and Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People's Hospital, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Biomater Sci. 2021 Aug 21;9(16):5437-5471. doi: 10.1039/d1bm00526j. Epub 2021 Jul 23.
In recent years, there has been rapid progress in MXene research due to its distinctive two-dimensional structure and outstanding properties. Especially in biomedical applications, MXenes have attracted widespread favor with numerous studies on biosafety, bioimaging, therapy, and biosensing, although their development is still in the experimental stage. A comprehensive understanding of the current status of MXenes in biomedicine will promote their use in clinical applications. Here, we review advances in MXene research. First, we introduce the methods of synthesis, surface modification and functionalization of MXenes. Then, we summarize the biosafety and biocompatibility, paving the way for specific biomedical applications. On this basis, MXene nanostructures are described with respect to their use in antibacterial, bioimaging, cancer therapy, tissue regeneration and biosensor applications. Finally, we discuss MXene as a promising candidate material for further applications in biomedicine.
近年来，由于 MXene 独特的二维结构和优异的性能，其研究取得了飞速的发展。特别是在生物医学应用中，MXene 因其在生物安全性、生物成像、治疗和生物传感等方面的研究而备受关注，尽管其发展仍处于实验阶段。全面了解 MXene 在生物医学中的现状将促进其在临床应用中的使用。在这里，我们综述了 MXene 研究的进展。首先，我们介绍了 MXene 的合成、表面改性和功能化方法。然后，我们总结了 MXene 的生物安全性和生物相容性，为其特定的生物医学应用铺平了道路。在此基础上，我们描述了 MXene 纳米结构在抗菌、生物成像、癌症治疗、组织再生和生物传感器应用方面的应用。最后，我们讨论了 MXene 作为一种有前途的候选材料，在生物医学领域有进一步的应用前景。
