Yang Ting, Shen Bangli, Wu Aiqin, Tang Xinglu, Chen Wei, Zhang Zhenzhong, Chen Bo, Guo Zhongwei, Liu Xiaozheng
The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Psychiatry. 2021 Jul 15;12:533428. doi: 10.3389/fpsyt.2021.533428. eCollection 2021.
Convergent evidence indicates that individuals with symptoms of depression exhibit altered functional connectivity (FC) of the amygdala, which is a key brain region in processing emotions. At present, the characteristics of amygdala functional circuits in patients with mild cognitive impairment (MCI) with and without depression are not clear. The current study examined the features of amygdala FC in patients with MCI with depression symptoms (D-MCI) using resting-state functional magnetic resonance imaging. We acquired resting-state functional magnetic resonance imaging data from 16 patients with D-MCI, 18 patients with MCI with no depression (nD-MCI), and 20 healthy controls (HCs) using a 3T scanner and compared the strength of amygdala FC between the three groups. Patients with D-MCI exhibited significant FC differences in the amygdala-medial prefrontal cortex and amygdala-sensorimotor networks. These results suggest that the dysfunction of the amygdala-medial prefrontal cortex network and the amygdala-sensorimotor network might be involved in the neural mechanism underlying depression in MCI.
多项证据表明，有抑郁症状的个体杏仁核的功能连接性（FC）发生改变，杏仁核是处理情绪的关键脑区。目前，伴有和不伴有抑郁的轻度认知障碍（MCI）患者杏仁核功能回路的特征尚不清楚。本研究使用静息态功能磁共振成像检查了有抑郁症状的MCI患者（D-MCI）杏仁核FC的特征。我们使用3T扫描仪从16例D-MCI患者、18例无抑郁的MCI患者（nD-MCI）和20名健康对照者（HCs）获取静息态功能磁共振成像数据，并比较了三组之间杏仁核FC的强度。D-MCI患者在杏仁核-内侧前额叶皮层和杏仁核-感觉运动网络中表现出显著的FC差异。这些结果表明，杏仁核-内侧前额叶皮层网络和杏仁核-感觉运动网络功能障碍可能参与了MCI患者抑郁的神经机制。
