Hou Miaomiao, Mao Xiaowei, Hou Xiaojun, Li Kunpeng
Department of Neurology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Department of Neurorehabilitation, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.
Front Psychiatry. 2021 Jul 15;12:708960. doi: 10.3389/fpsyt.2021.708960. eCollection 2021.
Stigmatizing experiences is common in Parkinson's disease (PD) and appears to provide a negative contribution to the quality of life. Our aim of this study was to investigate the extent of stigma and its predictive factors in patients with PD from our hospital in Shanghai, China. In 276 individuals with PD (135 women and 141 men), stigma was measured by the 24-item Stigma Scale for Chronic Illness (SSCI). Multivariate linear regression model was used to assess predictors of stigma including demographics (age and gender), disease duration, stage (Hoehn and Yahr Scale), motor function (Unified Parkinson's Disease Rating Scale Part 3, UPDRS-III), non-motor symptoms (Non-Motor Symptoms Scale, NMSS), cognitive level (Mini-Mental State Examination, MMSE), as well as anxiety (Hamilton Anxiety Rating Scale, HAM-A) and depressive disorders (Hamilton Depression Rating Scale, HAM-D-24). The total score of SSCI was 49.9 ± 14.3, and 48.5% of the patients checked "rarely" to "sometimes." For the total sample, the full model accounted for 47.8% of the variance in stigma ( < 0.05). Higher UPDRS-III scores, longer course of disease, younger age, tremor-dominant subtype, and higher depression scores were significantly associated with stigma among individuals with PD. Our finding suggested a mild-to-moderate level of stigma in patients with PD. Tremor-dominant subtype, longer course of disease, younger age, severe motor symptoms, and depression are the predictors of stigma in PD.
在帕金森病(PD)中,污名化经历很常见,并且似乎对生活质量产生负面影响。本研究的目的是调查中国上海我院帕金森病患者的污名化程度及其预测因素。在276例帕金森病患者(135名女性和141名男性)中,使用24项慢性病污名量表(SSCI)测量污名化程度。采用多元线性回归模型评估污名化的预测因素,包括人口统计学特征(年龄和性别)、病程、分期(霍恩和雅尔分级量表)、运动功能(统一帕金森病评定量表第3部分,UPDRS-III)、非运动症状(非运动症状量表,NMSS)、认知水平(简易精神状态检查表,MMSE),以及焦虑(汉密尔顿焦虑评定量表,HAM-A)和抑郁障碍(汉密尔顿抑郁评定量表,HAM-D-24)。SSCI的总分是49.9±14.3,48.5%的患者选择“很少”至“有时”。对于整个样本,完整模型解释了污名化变异的47.8%(<0.05)。较高的UPDRS-III评分、较长的病程、较年轻的年龄、震颤为主型亚型以及较高的抑郁评分与帕金森病患者的污名化显著相关。我们的研究结果表明帕金森病患者存在轻度至中度的污名化。震颤为主型亚型、较长的病程、较年轻的年龄、严重的运动症状和抑郁是帕金森病污名化的预测因素。