社区及住院治疗中呼吸道合胞病毒的全球流行病学：来自15个国家的研究结果
The Global Epidemiology of RSV in Community and Hospitalized Care: Findings From 15 Countries.
作者信息
Staadegaard Lisa, Caini Saverio, Wangchuk Sonam, Thapa Binay, de Almeida Walquiria Aparecida Ferreira, de Carvalho Felipe Cotrim, Njouom Richard, Fasce Rodrigo A, Bustos Patricia, Kyncl Jan, Novakova Ludmila, Caicedo Alfredo Bruno, de Mora Coloma Domenica Joseth, Meijer Adam, Hooiveld Mariëtte, Huang Sue, Wood Tim, Guiomar Raquel, Rodrigues Ana Paula, Danilenko Daria, Stolyarov Kirill, Lee Vernon Jian Ming, Ang Li Wei, Cohen Cheryl, Moyes Jocelyn, Larrauri Amparo, Delgado-Sanz Concepción, Le Mai Quynh, Hoang Phuong Vu Mai, Demont Clarisse, Bangert Mathieu, van Summeren Jojanneke, Dückers Michel, Paget John
机构信息
Nivel (Netherlands Institute for Health Services Research), Utrecht, the Netherlands.
Royal Centre for Disease Control, Ministry of Health, Thimphu, Bhutan.
出版信息
Open Forum Infect Dis. 2021 Mar 30;8(7):ofab159. doi: 10.1093/ofid/ofab159. eCollection 2021 Jul.
BACKGROUND
Respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infections. To optimize control strategies, a better understanding of the global epidemiology of RSV is critical. To this end, we initiated the Global Epidemiology of RSV in Hospitalized and Community care study (GERi).
METHODS
Focal points from 44 countries were approached to join GERi and share detailed RSV surveillance data. Countries completed a questionnaire on the characteristics of their surveillance system.
RESULTS
Fifteen countries provided granular surveillance data and information on their surveillance system. A median (interquartile range) of 1641 (552-2415) RSV cases per season were reported from 2000 and 2020. The majority (55%) of RSV cases occurred in the <1-year-olds, with 8% of cases reported in those aged ≥65 years. Hospitalized cases were younger than those in community care. We found no age difference between RSV subtypes and no clear pattern of dominant subtypes.
CONCLUSIONS
The high number of cases in the <1-year-olds indicates a need to focus prevention efforts in this group. The minimal differences between RSV subtypes and their co-circulation implies that prevention needs to target both subtypes. Importantly, there appears to be a lack of RSV surveillance data in the elderly.
背景
呼吸道合胞病毒（RSV）是急性呼吸道感染的主要病因之一。为优化防控策略，深入了解RSV的全球流行病学情况至关重要。为此，我们启动了住院和社区护理中RSV全球流行病学研究（GERi）。
方法
我们联系了44个国家的联络点，邀请其加入GERi并分享详细的RSV监测数据。各国完成了一份关于其监测系统特征的调查问卷。
结果
15个国家提供了详细的监测数据及监测系统信息。2000年至2020年期间，每个季节报告的RSV病例数中位数（四分位间距）为1641例（552 - 2415例）。大多数（55%）RSV病例发生在1岁以下儿童，65岁及以上人群中报告的病例占8%。住院病例比社区护理病例年龄更小。我们发现RSV各亚型之间不存在年龄差异，也没有明显的优势亚型模式。
结论
1岁以下儿童病例数众多，表明需要将预防工作重点放在该群体。RSV各亚型之间差异极小且共同流行，这意味着预防措施需要针对两种亚型。重要的是，老年人中似乎缺乏RSV监测数据。
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