使用多壁碳纳米管包覆聚（4-氨基-3-羟基萘磺酸）修饰玻碳电极伏安法测定尿酸

Voltammetric determination of uric acid using multiwall carbon nanotubes coated-poly(4-amino-3-hydroxy naphthalene sulfonic acid) modified glassy carbon electrode.

作者信息

Tefera Molla, Tessema Merid, Admassie Shimelis, Wubet Walelign

机构信息

Department of Chemistry, University of Gondar, P. O. Box 196, Gondar, Ethiopia.

Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia.

出版信息

Heliyon. 2021 Jul 15;7(7):e07575. doi: 10.1016/j.heliyon.2021.e07575. eCollection 2021 Jul.

In this study, an electrochemical sensor based multiwalled carbon nanotubes (MWCNTs)-poly (4-amino-3-hydroxy naphthalene sulfonic acid) modified glassy carbon electrode (MWCNTs/poly (AHNSA)/GCE) was developed for the determination of uric acid (UA). The composite electrode was prepared first by electropolymerization of the monomer (AHNSA) on GCE using cyclic voltammetry within the potential range of -0.8 V to +2.0 V Ag/AgCl for 15 cycles followed by drop coating of MWCNTs solution on the surface of poly (AHNSA)/GCE. Under optimal conditions, MWCNTs/poly (AHNSA)/GCE showed a linear current response with UA concentrations in the range of 1 × 10 to 1 × 10 M with R = 0.9972. The sensor exhibited low detection limit with a value of 0.024 μM. The sensors have been applied to successfully quantify UA in urine samples.