使用多壁碳纳米管包覆聚（4-氨基-3-羟基萘磺酸）修饰玻碳电极伏安法测定尿酸

Tefera Molla, Tessema Merid, Admassie Shimelis, Wubet Walelign

Department of Chemistry, University of Gondar, P. O. Box 196, Gondar, Ethiopia.

Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia.

Heliyon. 2021 Jul 15;7(7):e07575. doi: 10.1016/j.heliyon.2021.e07575. eCollection 2021 Jul.

In this study, an electrochemical sensor based multiwalled carbon nanotubes (MWCNTs)-poly (4-amino-3-hydroxy naphthalene sulfonic acid) modified glassy carbon electrode (MWCNTs/poly (AHNSA)/GCE) was developed for the determination of uric acid (UA). The composite electrode was prepared first by electropolymerization of the monomer (AHNSA) on GCE using cyclic voltammetry within the potential range of -0.8 V to +2.0 V Ag/AgCl for 15 cycles followed by drop coating of MWCNTs solution on the surface of poly (AHNSA)/GCE. Under optimal conditions, MWCNTs/poly (AHNSA)/GCE showed a linear current response with UA concentrations in the range of 1 × 10 to 1 × 10 M with R = 0.9972. The sensor exhibited low detection limit with a value of 0.024 μM. The sensors have been applied to successfully quantify UA in urine samples.

在本研究中，开发了一种基于电化学传感器的多壁碳纳米管（MWCNTs）-聚（4-氨基-3-羟基萘磺酸）修饰玻碳电极（MWCNTs/聚（AHNSA）/GCE）用于测定尿酸（UA）。首先通过循环伏安法在-0.8 V至+2.0 V（相对于Ag/AgCl）的电位范围内，在玻碳电极上对单体（AHNSA）进行15次循环的电聚合制备复合电极，然后将MWCNTs溶液滴涂在聚（AHNSA）/GCE表面。在最佳条件下，MWCNTs/聚（AHNSA）/GCE对UA浓度在1×10至1×10 M范围内呈现线性电流响应，相关系数R = 0.9972。该传感器具有0.024 μM的低检测限。这些传感器已成功应用于尿液样本中尿酸的定量分析。