Department of Neurology, Maltepe University, School of Medicine, Istanbul, Turkey.
Department of Neurology, University of Health Sciences, Sancaktepe Research and Training Hospital, Istanbul, Turkey.
Eur Neurol. 2021;84(6):450-459. doi: 10.1159/000517380. Epub 2021 Aug 3.
Coronavirus disease 2019 (COVID-19) pandemic and lockdown period may induce an impairment in quality of life (QoL), disruption in treatment (DIT), and posttraumatic stress disorder (PTSD) in chronic neurological diseases (CNDs). To reach this information, a multicenter, cross-sectional study (COVQoL-CND) was planned. Parkinson's disease (PD), headache (HA), multiple sclerosis (MS), epilepsy (EP), polyneuropathy (PNP), and cerebrovascular disease (CVD) were selected as the CND.
The COVQoL-CND study includes demographic data, the World Health Organization Quality of Life short form (WHOQOL-BREF), and Impact of Event Scale-Revised (IES-R) forms.
The mean age of a total of 577 patients was 49 ± 17 (19-87 years), and the ratio of female/male was 352/225. The mean age of patients with PD, HA, MS, EP, PNP, and CVD were 65 ± 11, 39 ± 12, 38 ± 10, 47 ± 17, 61 ± 12, and 60 ± 15 years, respectively. The IES-R scores were found to be higher in the younger group, those with comorbid disease, contacted with CO-VID-19 patients, or diagnosed with COVID-19. In the group with a high IES-R score, the rate of DIT was found to be high. IES-R scores were negatively correlated with QoL. IES-R total scores were found highest in the CVD group and lowest in the PD group. The ratio of DIT was found highest in the PNP group and the lowest in the EP group. Contact with CO-VID-19 patients was high in the EP and HA group.
The results of the COVQoL-CND study showed that lockdown causes posttraumatic stress and deterioration in the QoL in CND.
2019 年冠状病毒病（COVID-19）大流行和封锁期间，可能会导致慢性神经系统疾病（CND）的生活质量（QoL）受损、治疗中断（DIT）和创伤后应激障碍（PTSD）。为了获得这些信息，计划进行一项多中心、横断面研究（COVQoL-CND）。选择帕金森病（PD）、头痛（HA）、多发性硬化症（MS）、癫痫（EP）、多发性神经病（PNP）和脑血管病（CVD）作为 CND。
COVQoL-CND 研究包括人口统计学数据、世界卫生组织生活质量简表（WHOQOL-BREF）和修订后的事件影响量表（IES-R）。
共纳入 577 例患者，平均年龄为 49±17 岁（19-87 岁），男女比例为 352/225。PD、HA、MS、EP、PNP 和 CVD 患者的平均年龄分别为 65±11、39±12、38±10、47±17、61±12 和 60±15 岁。年轻组、合并症患者、接触 COVID-19 患者或确诊 COVID-19 的患者的 IES-R 评分较高。IES-R 评分高的患者中，DIT 发生率较高。IES-R 评分与 QoL 呈负相关。IES-R 总分在 CVD 组最高，PD 组最低。DIT 发生率在 PNP 组最高，EP 组最低。EP 和 HA 组接触 COVID-19 患者的比例较高。
COVQoL-CND 研究结果表明，封锁导致 CND 出现创伤后应激和 QoL 恶化。
