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使用全头颅面罩实现脑立体定向放射治疗中的分次内稳定性。

Intrafraction stability using full head mask for brain stereotactic radiotherapy.

机构信息

Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

Department of Radiology, Juntendo University Hospital, Tokyo, Japan.

出版信息

J Appl Clin Med Phys. 2021 Sep;22(9):360-370. doi: 10.1002/acm2.13382. Epub 2021 Aug 4.

Abstract

PURPOSE

We investigated the immobilization accuracy of a new type of thermoplastic mask-the Double Shell Positioning System (DSPS)-in terms of geometry and dose delivery.

METHODS

Thirty-one consecutive patients with 1-5 brain metastases treated with stereotactic radiotherapy (SRT) were selected and divided into two groups. Patients were divided into two groups. One group of patients was immobilized by the DSPS (n = 9). Another group of patients was immobilized by a combination of the DSPS and a mouthpiece (n = 22). Patient repositioning was performed with cone beam computed tomography (CBCT) and six-degree of freedom couch. Additionally, CBCT images were acquired before and after treatment. Registration errors were analyzed with off-line review. The inter- and intrafractional setup errors, and planning target volume (PTV) margin were also calculated. Delivered doses were calculated by shifting the isocenter according to inter- and intrafractional setup errors. Dose differences of GTV D were compared between planned and delivered doses against the modified PTV margin of 1 mm.

RESULTS

Interfractional setup errors associated with the mouthpiece group were significantly smaller than the translation errors in another group (p = 0.03). Intrafractional setup errors for the two groups were almost the same in all directions. PTV margins were 0.89 mm, 0.75 mm, and 0.90 mm for the DSPS combined with the mouthpiece in lateral, vertical, and longitudinal directions, respectively. Similarly, PTV margins were 1.20 mm, 0.72 mm, and 1.37 mm for the DSPS in the lateral, vertical, and longitudinal directions, respectively. Dose differences between planned and delivered doses were small enough to be within 1% for both groups.

CONCLUSIONS

The geometric and dosimetric assessments revealed that the DSPS provides sufficient immobilization accuracy. Higher accuracy can be expected when the immobilization is combined with the use of a mouthpiece.

摘要

目的

我们研究了一种新型热塑面罩——双壳定位系统(DSPS)的几何和剂量传递的固定精度。

方法

选择了 31 例接受立体定向放射治疗(SRT)治疗的 1-5 个脑转移瘤的连续患者,并将其分为两组。一组患者通过 DSPS(n=9)固定,另一组患者通过 DSPS 和口器的组合固定(n=22)。使用锥形束 CT(CBCT)和六自由度床进行患者复位。此外,在治疗前后还获取了 CBCT 图像。通过离线审查分析注册误差。还计算了分次内和分次间的设置误差以及计划靶区(PTV)边界。根据分次内和分次间的设置误差,通过移动等中心点计算了传递剂量。比较了 GTV D 的计划剂量与传递剂量之间的剂量差异,并针对修改后的 1mm PTV 边界进行了比较。

结果

口器组的分次间设置误差明显小于另一组的平移误差(p=0.03)。两组的分次内设置误差在各个方向上几乎相同。DSPS 联合口器在侧向、垂直和纵向方向上的 PTV 边界分别为 0.89mm、0.75mm 和 0.90mm。同样,DSPS 在侧向、垂直和纵向方向上的 PTV 边界分别为 1.20mm、0.72mm 和 1.37mm。两组的计划剂量与传递剂量之间的剂量差异足够小,均在 1%以内。

结论

几何和剂量评估表明,DSPS 提供了足够的固定精度。当固定与使用口器结合时,可以预期更高的精度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c11b/8425876/6adb74fa158a/ACM2-22-360-g002.jpg

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