School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.
Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2021 Nov;35(11):6101-6113. doi: 10.1002/ptr.7219. Epub 2021 Aug 5.
Cardiovascular diseases (CVDs) comprise the most prevalent causes of morbidity and mortality in both men and women worldwide. CVDs are associated with several risk factors such as hyperlipidemia, diabetes mellitus, hypertension, obesity, tobacco smoking and an unhealthy diet. Currently, in addition to the use of related pharmacological treatments in the management of CVDs, the investigation of other suitable healthcare approaches for these disorders such as the identification of herbal medicines has been considered in the scientific communities. Aloe vera (L.) Burm.f. is a perennial medicinal plant. The innermost leaf layer of this plant contains transparent gel, which is used as food. Pre-clinical studies have shown several biological activities of A. vera gel (AVG), including antidiabetic, lipid-lowering, antioxidant, antiinflammatory, hepatoprotective, and immunomodulatory effects. Other pharmacological activities of AVG such as anti-fibrotic, anti-hypertensive, and anti-atherosclerotic effects have been reported. Moreover, several clinical studies have demonstrated the ameliorating effects of AVG on some markers of CVDs risk factors. Thus, this study was conducted to review clinical trials besides in vitro and in vivo studies on the cardiac beneficial effects of AVG. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.
心血管疾病（CVDs）是全球男性和女性发病率和死亡率最高的主要原因。CVDs 与多种风险因素有关，如高血脂、糖尿病、高血压、肥胖、吸烟和不健康的饮食。目前，除了在 CVDs 管理中使用相关的药物治疗外，科学界还在研究其他适合这些疾病的医疗保健方法，如识别草药。芦荟（L.）Burm.f. 是一种多年生药用植物。这种植物的最内层叶层含有透明凝胶，可用作食品。临床前研究表明，芦荟凝胶（AVG）具有多种生物学活性，包括降血糖、降血脂、抗氧化、抗炎、保肝和免疫调节作用。AVG 还具有抗纤维化、抗高血压和抗动脉粥样硬化等其他药理作用。此外，几项临床研究表明，AVG 可改善 CVDs 风险因素的一些标志物。因此，本研究旨在综述 AVG 对心脏有益作用的临床前和临床研究，除了体外和体内研究。然而，需要进一步进行高质量的研究来确定该植物的临床疗效。
