Department of Internal Medicine, Zaans Medical Centre, Zaandam, the Netherlands.
Department of Medical Microbiology, Comicro, Hoorn, the Netherlands.
Int J Infect Dis. 2021 Oct;111:169-171. doi: 10.1016/j.ijid.2021.08.048. Epub 2021 Aug 21.
COVID-19 presents in various ways, but mainly as a pulmonary disease (Marzano, 2020). Skin manifestations have been reported, including reactivation of the varicella-zoster virus (Marzano, 2020). Our case report describes two adults developing herpes zoster after vaccination with tozinameran (the Pfizer-BioNTech COVID-19 mRNA vaccine). A possible cause for this reaction is a transient lymphocytopenia that occurs after the vaccination - similar to that in COVID-19 disease (Mulligan, 2020; Wang, 2020; Qin, 2020; Brabilla, 2020; Wang, 2020; Wei, 2017). In the context of vaccinating older and/or immunocompromised adults, our observations can be the starting point for further evaluation of a possible relationship between COVID-19, COVID vaccines, and herpes zoster.
COVID-19 以多种方式出现，但主要是肺部疾病（Marzano，2020）。已报告皮肤表现，包括水痘带状疱疹病毒（Marzano，2020）的再激活。我们的病例报告描述了两名成年人在接种 tozinameran（辉瑞-生物科技公司的 COVID-19 mRNA 疫苗）后出现带状疱疹。这种反应的一个可能原因是接种后发生的短暂淋巴细胞减少症 - 类似于 COVID-19 疾病（Mulligan，2020；Wang，2020；Qin，2020；Brabilla，2020；Wang，2020；Wei，2017）。在为老年和/或免疫功能低下的成年人接种疫苗的情况下，我们的观察结果可以作为进一步评估 COVID-19、COVID 疫苗和带状疱疹之间可能存在的关系的起点。
