Lisbona-González Maria Jesús, Muñoz-Soto Esther, Lisbona-González Cristina, Vallecillo-Rivas Marta, Diaz-Castro Javier, Moreno-Fernandez Jorge
Department of Stomatology, School of Dentistry, University of Granada, 18071 Granada, Spain.
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain.
Plants (Basel). 2021 Aug 4;10(8):1603. doi: 10.3390/plants10081603.
This study investigated the antimicrobial effects of a mouthwash containing propolis and the effect of a propolis paste formulation on dental healing after teeth extraction in patients with periodontal disease. In the mouthwash experience, the population comprised 40 patients, which were divided as follows: the control mouthwash, 0.2% chlorhexidine (v/v) mouthwash, 2% (w/v) propolis mouthwash, and propolis + chlorhexidine mouthwash. The study of the propolis paste comprised a population of 60 patients with periodontal disease, and a total of 120 symmetric tooth extractions were performed. Propolis showed antimicrobial activity by itself, and especially with the chlorhexidine association. Three days after surgery in the teeth treated with control paste, only 13.4% had completely healed; however, with propolis paste, in 90% of the periodontal sockets, healing was complete. In addition, a reduction in and cfu was observed with propolis, and especially with the association of chlorhexidine + propolis. Propolis mouthwash reduced bacterial proliferation, especially in association with chlorhexidine. Propolis paste is a viable alternative for socket healing after dental extraction. The knowledge gained from these findings will provide a foundation for similar propolis therapies in order to improve the healing process after dental surgery.
本研究调查了含蜂胶漱口水的抗菌效果以及蜂胶糊剂配方对牙周病患者拔牙后牙齿愈合的影响。在漱口水实验中，研究对象包括40名患者，分组如下：对照漱口水组、0.2%氯己定（体积比）漱口水组、2%（质量比）蜂胶漱口水组以及蜂胶+氯己定漱口水组。蜂胶糊剂的研究对象为60名牙周病患者，共进行了120次对称牙拔除。蜂胶自身具有抗菌活性，尤其是与氯己定联合使用时。使用对照糊剂治疗的牙齿在术后三天，只有13.4%完全愈合；然而，使用蜂胶糊剂时，90%的牙周窝实现了完全愈合。此外，观察到使用蜂胶，尤其是氯己定+蜂胶联合使用时，菌落形成单位减少。蜂胶漱口水可减少细菌增殖，尤其是与氯己定联合使用时。蜂胶糊剂是拔牙后牙槽窝愈合的一种可行替代方法。从这些研究结果中获得的知识将为类似的蜂胶疗法提供基础，以改善牙科手术后的愈合过程。
