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本文引用的文献

1
COVID-19-related dermatosis in November 2019: could this case be Italy's patient zero?2019年11月与新型冠状病毒肺炎相关的皮肤病：该病例会是意大利的“零号病人”吗？
Br J Dermatol. 2021 May;184(5):970-971. doi: 10.1111/bjd.19804. Epub 2021 Feb 18.
2
Infection of human sweat glands by SARS-CoV-2.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染人体汗腺。
Cell Discov. 2020 Nov 13;6(1):84. doi: 10.1038/s41421-020-00229-y.
3
Impaired type I interferon response in SARS-CoV-2 infection: looking through the cutaneous window.SARS-CoV-2 感染中 I 型干扰素反应受损：透过皮肤之窗观察。
Br J Dermatol. 2021 Jan;184(1):11-12. doi: 10.1111/bjd.19596. Epub 2020 Nov 29.
4
Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic.COVID-19 大流行期间冻疮样皮损患者的临床、实验室和干扰素-α反应特征。
JAMA Dermatol. 2021 Feb 1;157(2):202-206. doi: 10.1001/jamadermatol.2020.4324.
5
Similarities in Cutaneous Histopathological Patterns between COVID-19-positive and COVID-19 High-risk Patients with Skin Dermatosis.COVID-19 阳性患者与 COVID-19 高风险伴皮肤疾病患者的皮肤组织病理形态学表现存在相似性。
Acta Derm Venereol. 2020 Aug 19;100(15):adv00249. doi: 10.2340/00015555-3612.
6
Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infection by COVID-19 in the Northern Part of Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases.意大利北部受新冠病毒感染或高度疑似感染的患者多种皮肤疾病的组织病理学研究：既往及新报告病例中病毒诱导性皮肤病的多面分析
Am J Dermatopathol. 2020 Aug;42(8):564-570. doi: 10.1097/DAD.0000000000001707.
7
Most chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on polymerase chain reaction and serology testing.在 COVID-19 疫情期间观察到的大多数冻疮样疹发生在聚合酶链反应和血清学检测 COVID-19 为阴性的患者中。
Br J Dermatol. 2020 Nov;183(5):866-874. doi: 10.1111/bjd.19377. Epub 2020 Aug 9.
8
COVID-19 chilblain-like lesion: immunohistochemical demonstration of SARS-CoV-2 spike protein in blood vessel endothelium and sweat gland epithelium in a polymerase chain reaction-negative patient.新冠病毒-19冻疮样病变：聚合酶链反应阴性患者血管内皮和汗腺上皮中严重急性呼吸综合征冠状病毒2刺突蛋白的免疫组织化学证实
Br J Dermatol. 2020 Oct;183(4):778-780. doi: 10.1111/bjd.19338. Epub 2020 Jul 29.
9
Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue.新型冠状病毒肺炎患者的皮肤表现：一个新出现问题的初步综述
Br J Dermatol. 2020 Sep;183(3):431-442. doi: 10.1111/bjd.19264. Epub 2020 Jul 5.
10
Chilblain-like lesions in children following suspected COVID-19 infection.疑似新型冠状病毒肺炎感染后儿童出现的冻疮样病变
Pediatr Dermatol. 2020 May;37(3):437-440. doi: 10.1111/pde.14210. Epub 2020 Jun 1.

儿童丘疹脓疱性皮炎：一种与 SARS-CoV-2 感染相关的独特的 PLEVA 样疹。10 例临床、组织病理学和免疫组化研究。

Papulo-purpuric dermatitis of childhood: a distinct PLEVA-like eruption associated to SARS-CoV-2 infection. Clinical, histopathological and immunohistochemical study of 10 cases.

机构信息

Department of Pathophysiology and Transplantation, Dermatology Unit, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Department of Clinical Sciences and Community Health, Pediatric Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

出版信息

Pediatr Dermatol. 2021 Sep;38(5):1185-1190. doi: 10.1111/pde.14777. Epub 2021 Aug 31.

DOI:10.1111/pde.14777
PMID:34463363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8646411/
Abstract

We observed ten children with a papular eruption with purpuric features during the SARS-CoV-2 pandemic in Northern Italy (May-December 2020). Histological examination showed signs of SARS-CoV-2-related dermatosis. Evidence of nucleocapsid viral proteins using SARS-CoV-2 (2019-nCoV) nucleocapsid antibody revealed cuticular staining of the deep portion of the eccrine glands in all cases.

摘要

我们在意大利北部 SARS-CoV-2 大流行期间观察到 10 例具有紫癜特征的丘疹性发疹患儿（2020 年 5 月至 12 月）。组织学检查显示与 SARS-CoV-2 相关的皮肤病迹象。使用 SARS-CoV-2（2019-nCoV）核衣壳抗体检测核衣壳病毒蛋白的证据显示，所有病例的外分泌腺深部均有角质层染色。