Division of Ophthalmology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Graefes Arch Clin Exp Ophthalmol. 2022 Jan;260(1):209-214. doi: 10.1007/s00417-021-05315-9. Epub 2021 Aug 31.
To investigate the effects of mental stress stimulus on intraocular pressure (IOP) measurement and visual field (VF) testing.
Patients with open angle glaucoma underwent a baseline IOP measurement and VF testing. Afterwards, they completed a computerized mental stress test (Stroop test) which is a known standardized method to induce mental stress. After test completion, patients underwent a second IOP measurement and VF testing.
Seventy-two eyes of 36 patients were enrolled. Mean age was 67.0 ± 9.5 years (range 47-84 years). The mean baseline IOP was 15.0 mmHg, and after the Stroop mental stress test, IOP increased to 16.0 mm Hg (P < 0.001). There was a trend towards significant mean deviation decreased from -6.9 dB to -8.0 dB (P = 0.054, t-test) following the stress test. This difference became significant using the Wilcoxon nonparametric test (P = 0.008). Correlation was found between glaucoma severity and change in IOP (P = 0.02) and PSD (P < 0.01).
We found a small but statistically significant increase in IOP and a trend towards deterioration of visual field mean deviation, following a short mental stress test. Patients with more severe glaucoma showed more pronounced changes. Our results suggest that mental stress could affect IOP measurement in the clinic.
研究心理应激刺激对眼压（IOP）测量和视野（VF）检查的影响。
开角型青光眼患者进行基线 IOP 测量和 VF 检查。然后，他们完成了一项计算机化的心理应激测试（Stroop 测试），这是一种已知的标准化方法来诱发心理应激。测试完成后，患者进行第二次 IOP 测量和 VF 检查。
36 例患者的 72 只眼纳入研究。平均年龄为 67.0±9.5 岁（47-84 岁）。平均基线 IOP 为 15.0mmHg，Stroop 心理应激测试后 IOP 升高至 16.0mmHg（P<0.001）。VF 平均偏差有从-6.9dB 向-8.0dB 显著下降的趋势（P=0.054，t 检验），但这种差异在使用 Wilcoxon 非参数检验时具有统计学意义（P=0.008）。IOP 和 PSD 的变化与青光眼严重程度呈正相关（P=0.02 和 P<0.01）。
我们发现，在进行短暂的心理应激测试后，IOP 有一个小但具有统计学意义的升高，VF 平均偏差也有恶化的趋势。青光眼严重程度较高的患者变化更为明显。我们的研究结果表明，心理应激可能会影响临床中的 IOP 测量。
