Rabbani Syed Imam, Sajid Sultan, Mani Vasudevan, Afroz Salman Mohammed, Khan Omar, Asdaq Syed Mohammed Basheeruddin, Yasmin Farhana, Alamri Abdulhakeem S, Alsanie Walaa F, Alhomrani Majid, Mohzari Yahya, Alrashed Ahmed, Alajami Hamdan Najib, Aljohani Awad Othman, Alamer Rakan Fahad, Alanazi Abdulmajead Khalid
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
Saudi J Biol Sci. 2021 Sep;28(9):4931-4937. doi: 10.1016/j.sjbs.2021.04.094. Epub 2021 May 30.
BACKGROUND & OBJECTIVES: Cigarette smoke is associated with several diseased states including defects in reproductive behavior. () known as the toothbrush plant is reported to possess several pharmacological properties including antidepressants and anxiolytics. The present research was done to determine the libido-protective effect of in chronic cigarette smoke-exposed rats.
The decoction of freshly dried roots of (50, 100, and 200 mg/kg, oral) was administered to the chronic-cigarette smoke-exposed adult rats. The parameters related to libido were recorded using a close-camera circuit (CCTV). Serum corticosterone and testosterone levels were estimated. Further, the phytochemical constituents were identified in the decoction. The data obtained were analyzed using one-way analysis of variance and significance was considered at p < 0.05.
The observation from the study revealed that cigarette smoke exposure reduces the sexual activity parameters significantly (p < 0.01), besides elevated the serum corticosterone and suppressed the testosterone levels in rats. Administration of at 200 mg/kg improved significantly (p < 0.05) the parameters related to libido. The decoction also reversed the changes in the levels of tested hormones in serum.
The findings indicate that a 200 mg/kg decoction can protect libido in chronic cigarette smoke-exposed rats. The activity may be due to the presence of several phytoconstituents such as alkaloid, flavonoids and phytosterols that might produce vasodilatory effect in sex organs and enhance the synthesis of endogenous testosterone to improve libido characteristics weakened by chronic cigarette smoke exposure.
香烟烟雾与多种疾病状态相关，包括生殖行为缺陷。（）被称为牙刷植物，据报道具有多种药理特性，包括抗抑郁和抗焦虑作用。本研究旨在确定（）对慢性暴露于香烟烟雾的大鼠的性欲保护作用。
将新鲜干燥的（）根的水煎剂（50、100和200mg/kg，口服）给予慢性暴露于香烟烟雾的成年大鼠。使用闭路摄像系统（CCTV）记录与性欲相关的参数。测定血清皮质酮和睾酮水平。此外，鉴定了水煎剂中的植物化学成分。所得数据采用单因素方差分析进行分析，p<0.05时认为具有显著性。
研究观察结果显示，香烟烟雾暴露显著降低了大鼠的性活动参数（p<0.01），同时升高了血清皮质酮水平并抑制了睾酮水平。给予200mg/kg的（）显著改善了（p<0.05）与性欲相关的参数。水煎剂还逆转了血清中受试激素水平的变化。
研究结果表明，200mg/kg的（）水煎剂可保护慢性暴露于香烟烟雾的大鼠的性欲。该作用可能归因于生物碱、黄酮类化合物和植物甾醇等多种植物成分的存在，这些成分可能在性器官产生血管舒张作用，并增强内源性睾酮的合成，以改善因慢性香烟烟雾暴露而减弱的性欲特征。
