Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Vet Surg. 2021 Nov;50(8):1634-1643. doi: 10.1111/vsu.13711. Epub 2021 Sep 1.
To evaluate the effect of a proprietary Manuka honey essential oil hydrogel on the healing of acute, full-thickness wounds in dogs.
Prospective, controlled, randomized, experimental study.
Purpose-bred, adult, female beagles (n = 10).
Two 2 × 2 cm surgical wounds were created bilaterally on the trunk of each dog; each side was randomized to receive HoneyCure® (HOC) or standard-of-care (CON) dressings. Cranial wounds were for histopathological analysis and the caudal wounds for culture and planimetry. Total and open wound areas were measured with digital image planimetry at 15 time points. From these data, percent contraction and percent epithelialization were calculated. Tissue biopsies were obtained at 7 time points and histologic features scored. Cultures were obtained at 2 time points.
Epithelialization was 11.7, 10.4, and 10.1 percentage points higher in HOC wounds compared to CON wounds at days 16, 18, and 21 respectively. Wound contraction and histological scores did not differ between groups. Cultures were positive in 7/40 (17.5%) wounds, with Staphylococcus pseudintermedius and Staphylococcus epidermidis isolated evenly. There was no difference of infection rate between the two groups; all infections were superficial and did not require treatment.
This study did not provide evidence to support the application of HoneyCure® in small, acute wounds in healthy dogs. However, application may be beneficial in the early proliferative stage of wound healing and in wounds that would benefit from early, robust epithelialization.
评估一种专利麦卢卡蜂蜜精油水凝胶对犬急性全层伤口愈合的影响。
前瞻性、对照、随机、实验研究。
专门饲养的成年雌性比格犬（n=10）。
在每只狗的躯干两侧各创建两个 2×2 厘米的手术伤口；每侧随机接受 HoneyCure®（HOC）或标准护理（CON）敷料。头部伤口用于组织病理学分析，尾部伤口用于培养和平面图测量。在 15 个时间点使用数字图像平面图测量总伤口和开放伤口面积。根据这些数据，计算出收缩百分比和上皮化百分比。在 7 个时间点获取组织活检标本，并对组织学特征进行评分。在 2 个时间点获取培养物。
HOC 组伤口的上皮化率在第 16、18 和 21 天分别比 CON 组高 11.7、10.4 和 10.1 个百分点。两组间伤口收缩和组织学评分无差异。培养物在 7/40（17.5%）个伤口中呈阳性，分离出金黄色葡萄球菌中间亚种和表皮葡萄球菌。两组间感染率无差异；所有感染均为浅表性，无需治疗。
本研究未提供证据支持在健康犬的小面积急性伤口中应用 HoneyCure®。然而，在伤口愈合的早期增殖阶段和需要早期、强劲上皮化的伤口中，应用可能是有益的。
