Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44240, USA.
Chem Soc Rev. 2021 Nov 1;50(21):11966-11978. doi: 10.1039/d1cs00250c.
Invention of DNA origami has transformed the fabrication and application of biological nanomaterials. In this review, we discuss DNA origami nanoassemblies according to their four fundamental mechanical properties in response to external forces: elasticity, pliability, plasticity and stability. While elasticity and pliability refer to reversible changes in structures and associated properties, plasticity shows irreversible variation in topologies. The irreversible property is also inherent in the disintegration of DNA nanoassemblies, which is manifested by its mechanical stability. Disparate DNA origami devices in the past decade have exploited the mechanical regimes of pliability, elasticity, and plasticity, among which plasticity has shown its dominating potential in biomechanical and physiochemical applications. On the other hand, the mechanical stability of the DNA origami has been used to understand the mechanics of the assembly and disassembly of DNA nano-devices. At the end of this review, we discuss the challenges and future development of DNA origami nanoassemblies, again, from these fundamental mechanical perspectives.
DNA 折纸的发明改变了生物纳米材料的制造和应用。在这篇综述中，我们根据 DNA 折纸纳米组装体在响应外力时的四个基本机械性能进行讨论：弹性、柔韧性、塑性和稳定性。虽然弹性和柔韧性是指结构和相关性质的可逆变化，但塑性则表现出拓扑结构的不可逆变化。这种不可逆性也存在于 DNA 纳米组装体的解体中，这表现为其机械稳定性。在过去十年中，不同的 DNA 折纸器件利用了柔韧性、弹性和塑性的力学状态，其中塑性在生物力学和物理化学应用中显示出了其主导潜力。另一方面，DNA 折纸的机械稳定性被用于理解 DNA 纳米器件的组装和拆卸的力学。在这篇综述的最后，我们再次从这些基本的机械角度讨论了 DNA 折纸纳米组装体的挑战和未来发展。
