School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China.
School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Nano Lett. 2021 Oct 13;21(19):8086-8094. doi: 10.1021/acs.nanolett.1c02441. Epub 2021 Sep 24.
Inspired by the tactic organisms in Nature that can self-direct their movement following environmental stimulus gradient, we proposed a DNase functionalized Janus nanoparticle (JNP) nanomotor system for the first time, which can be powered by ultralow nM to μM levels of DNA. The system exhibited interesting chemotactic behavior toward a DNA richer area, which is physiologically related with many diseases including tumors. In the presence of the subtle DNA gradient generated by apoptotic tumor cells, the cargo loaded nanomotors were able to sense the DNA signal released by the cells and demonstrate directional motion toward tumor cells. For our system, the subtle DNA gradient by a small amount (10 μL) of tumor cells is sufficient to induce the chemotaxis behavior of self-navigating and self-targeting ability of our nanomotor system, which promises to shed new light for tumor diagnosis and therapy.
受自然界中能够根据环境刺激梯度自主引导运动的生物策略的启发，我们首次提出了一种 DNA 酶功能化的 Janus 纳米颗粒（JNP）纳米马达系统，该系统可以在超低 nM 至 μM 水平的 DNA 驱动下工作。该系统表现出对富含 DNA 区域的趋化行为，这与包括肿瘤在内的许多疾病在生理上有关。在由凋亡肿瘤细胞产生的微妙 DNA 梯度存在的情况下，负载货物的纳米马达能够感知到细胞释放的 DNA 信号，并表现出朝向肿瘤细胞的定向运动。对于我们的系统，少量（10 μL）肿瘤细胞产生的微妙 DNA 梯度足以诱导自主导航和自我靶向能力的趋化行为，这为肿瘤诊断和治疗带来了新的希望。
