Mousavi Seyyed-Mojtaba, Nejad Zohre Mousavi, Hashemi Seyyed Alireza, Salari Marjan, Gholami Ahmad, Ramakrishna Seeram, Chiang Wei-Hung, Lai Chin Wei
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Biotechnology Research Center and Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Shiraz University of Medical Science, Shiraz 71345-1583, Iran.
Membranes (Basel). 2021 Sep 13;11(9):702. doi: 10.3390/membranes11090702.
Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.
尽管迄今为止在开发伤口敷料方面已经取得了进展，但伤口愈合在医疗保健系统中仍然是一项挑战。目前临床上使用的伤口敷料均无法模拟正常健康皮肤的所有特性。由于静电纺丝具有形成类似于天然细胞外基质（ECM）的纳米结构的出色能力，因此在伤口愈合应用中受到了显著关注。静电纺丝敷料通过更快地将药物或活性剂转移到伤口部位来加速伤口愈合过程。本综述简要概述了生物活性静电纺丝敷料的最新进展，这些敷料在治疗急性和慢性伤口方面有效，并且能够成功治愈伤口。我们还讨论了用于制备静电纺丝伤口敷料以提高其在伤口愈合中治疗潜力的生物活性剂。此外，我们在此展示了负载生物活性剂的商业敷料，并比较了它们的特性和功能。此外，我们讨论了挑战和前景，并为未来关于负载生物活性剂的纳米纤维膜的研究提供建议，以指导未来的研究人员设计更有效的伤口愈合和皮肤再生敷料。
