School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
Molecules. 2023 Jan 8;28(2):641. doi: 10.3390/molecules28020641.
The present chemical investigation on the organic extract of the soft coral has contributed to the isolation of four new cembranoids: 16- and 16-hydroperoxyisosarcophytoxides ( and ), 16- and 16-methoxyisosarcophytoxides ( and ), and a known cembranoid, lobocrasol (). The structures of all isolates were elucidated by detailed spectroscopic analysis. Their structures were characterized by a 2,5-dihydrofuran moiety, of which the relative configuration was determined by DU8-based calculation for long-range coupling constants (). The cytotoxicity and immunosuppressive activities of all isolates were evaluated in this study.
16-和 16-过氧异沙蟾毒精（和），16-和 16-甲氧基异沙蟾毒精（和），以及一种已知的海鞘素，洛可沙醇（）。所有分离物的结构均通过详细的光谱分析阐明。它们的结构特征是具有 2,5-二氢呋喃部分，其相对构型通过基于 DU8 的长程耦合常数（）计算来确定。在这项研究中评估了所有分离物的细胞毒性和免疫抑制活性。
