Nomura A, Heilbrun L K, Stemmermann G N
J Natl Cancer Inst. 1986 Apr;76(4):587-90. doi: 10.1093/jnci/76.4.587.
Information on coffee consumption was obtained from 7,355 men clinically examined from 1965 to 1968, as part of a prospective cohort study. Since examination, the following numbers of newly diagnosed cancer cases have been identified: 110 lung, 108 colon, 108 prostate, 106 stomach, 60 rectum, 39 bladder, 21 pancreas, and 120 other sites. Coffee intake did not significantly increase the risk for any of the cancers in this study. There was a slight suggestion of a positive association between heavy coffee intake and the risk for lung and urinary bladder cancer, but it could be attributed to the confounding effects of cigarette smoking among the male coffee drinkers. Overall, there was no strong evidence that coffee intake increased the risk for any of the common cancers in this study.
作为一项前瞻性队列研究的一部分，关于咖啡摄入量的信息来自于1965年至1968年接受临床检查的7355名男性。自检查以来，已确定了以下新诊断的癌症病例数：肺癌110例、结肠癌108例、前列腺癌108例、胃癌106例、直肠癌60例、膀胱癌39例、胰腺癌21例以及其他部位120例。在本研究中，咖啡摄入量并未显著增加任何一种癌症的风险。有轻微迹象表明大量饮用咖啡与肺癌和膀胱癌风险之间存在正相关，但这可能归因于男性咖啡饮用者中吸烟的混杂效应。总体而言，没有强有力的证据表明在本研究中咖啡摄入量会增加任何一种常见癌症的风险。
