Liao Min-Tser, Wu Chia-Chao, Wu Shu-Fang Vivienne, Lee Mei-Chen, Hu Wan-Chung, Tsai Kuo-Wang, Yang Chung-Hsiang, Lu Chien-Lin, Chiu Sheng-Kang, Lu Kuo-Cheng
Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan City 325, Taiwan.
Department of Pediatrics, Taoyuan Armed Forces General Hospital Hsinchu Branch, Hsinchu City 300, Taiwan.
Antioxidants (Basel). 2021 Sep 9;10(9):1440. doi: 10.3390/antiox10091440.
The coronavirus disease 2019 (COVID-19) pandemic continues to burden healthcare systems worldwide. COVID-19 symptoms are highly heterogeneous, and the patient may be asymptomatic or may present with mild to severe or fatal symptoms. Factors, such as age, sex, and comorbidities, are key determinants of illness severity and progression. Aging is accompanied by multiple deficiencies in interferon production by dendritic cells or macrophages in response to viral infections, resulting in dysregulation of inflammatory immune responses and excess oxidative stress. Age-related dysregulation of immune function may cause a more obvious pathophysiological response to SARS-CoV-2 infection in elderly patients and may accelerate the risk of biological aging, even after recovery. For more favorable treatment outcomes, inhibiting viral replication and dampening inflammatory and oxidative responses before induction of an overt cytokine storm is crucial. Resveratrol is a potent antioxidant with antiviral activity. Herein, we describe the reasons for impaired interferon production, owing to aging, and the impact of aging on innate and adaptive immune responses to infection, which leads to inflammation distress and immunosuppression, thereby causing fulminant disease. Additionally, the molecular mechanism by which resveratrol could reverse a state of excessive basal inflammatory and oxidative stress and low antiviral immunity is discussed.
2019冠状病毒病（COVID-19）大流行继续给全球医疗系统带来负担。COVID-19症状高度异质，患者可能无症状，也可能表现出从轻症到重症甚至致命的症状。年龄、性别和合并症等因素是疾病严重程度和进展的关键决定因素。衰老伴随着树突状细胞或巨噬细胞在应对病毒感染时干扰素产生的多种缺陷，导致炎症免疫反应失调和氧化应激过度。与年龄相关的免疫功能失调可能导致老年患者对SARS-CoV-2感染产生更明显的病理生理反应，甚至在康复后也可能加速生物衰老的风险。为了获得更有利的治疗结果，在明显的细胞因子风暴诱导之前抑制病毒复制并减轻炎症和氧化反应至关重要。白藜芦醇是一种具有抗病毒活性的强效抗氧化剂。在此，我们描述了由于衰老导致干扰素产生受损的原因，以及衰老对感染的固有免疫和适应性免疫反应的影响，这会导致炎症应激和免疫抑制，从而引发暴发性疾病。此外，还讨论了白藜芦醇能够逆转基础炎症和氧化应激过度以及抗病毒免疫力低下状态的分子机制。
