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白桦脂酸二磷酸在细菌纤维素-ZnO NPs 创伤敷料中对血小板聚集的影响，以及对烧伤大鼠 NAD(P)+/NAD(P)H 平衡调控的氧化还原酶活性的影响。

The Effect of Betulin Diphosphate in Wound Dressings of Bacterial Cellulose-ZnO NPs on Platelet Aggregation and the Activity of Oxidoreductases Regulated by NAD(P)+/NAD(P)H-Balance in Burns on Rats.

机构信息

Faculty of Chemistry, Lobachevsky University, 23/5 Gagarin Av., 603950 Nizhny Novgorod, Russia.

Department of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.

出版信息

Molecules. 2021 Sep 9;26(18):5478. doi: 10.3390/molecules26185478.

DOI:10.3390/molecules26185478
PMID:34576949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8469126/
Abstract

The inhibition of platelet aggregation, and the activity of oxidoreductases and microhemocirculation in a burn wound on the treatment of burns with wound dressings based on bacterial nanocellulose (BC)-zinc oxide nanoparticles (ZnO NPs)-betulin diphosphate (BDP) were studied. The control of the treatment by BC-ZnO NPs-BDP on burned rats by the noninvasive DLF method showed an increase in perfusion and the respiratory component in wavelet spectra, characterizing an improvement in oxygen saturation in the wound. The study on the volunteers' blood found the inhibition of ADP-induced platelet aggregation by 30-90%. Disaggregation depends on the dose under the action of the ionized form of BDP and ZnO NPs-BDP in a phosphate buffer; it was reversible and had two waves. It was shown on rats that the specific activity of LDH and LDH (control-intact animals) on day 21 of treatment increased by 11-38% and 23%, respectively. The LDH/LDH ratio increased at BC-ZnO NPs-BDP treatment, which characterizes efficient NAD+ regeneration. AlDH activity increased significantly in the first 10 days by 70-170%, reflecting the effectiveness of the enzyme and NAD+ in utilizing toxic aldehydes at this stage of burn disease. The activities of GR and G6PDH using NADP(H) were increased with BC-ZnO NPs-BDP treatment.

摘要

研究了基于细菌纳米纤维素 (BC)-氧化锌纳米粒子 (ZnO NPs)-白桦脂二磷酸 (BDP) 的伤口敷料治疗烧伤时对血小板聚集抑制和氧化还原酶活性及微血液循环的影响。通过非侵入性 DLF 方法对烧伤大鼠进行的 BC-ZnO NPs-BDP 治疗控制表明，灌流和小波谱中的呼吸分量增加，表明伤口的氧饱和度提高。对志愿者血液的研究发现，ADP 诱导的血小板聚集抑制率为 30-90%。在磷酸盐缓冲液中，BDP 和 ZnO NPs-BDP 的离子形式作用下，解聚取决于剂量；它是可逆的，有两个波。在大鼠中表明，在治疗的第 21 天，LDH 和 LDH（对照-完整动物）的比活性分别增加了 11-38%和 23%。BC-ZnO NPs-BDP 治疗时 LDH/LDH 比值增加，这表明 NAD+再生效率高。在烧伤疾病的这个阶段，ALDH 活性在 10 天内显著增加了 70-170%，反映了酶和 NAD+利用有毒醛的有效性。使用 NADP（H）的 GR 和 G6PDH 活性增加了 BC-ZnO NPs-BDP 治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/3a128e18f9b7/molecules-26-05478-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/a02282d59a8a/molecules-26-05478-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/ec9b89d781ee/molecules-26-05478-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/305d358916c3/molecules-26-05478-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/491845d941c0/molecules-26-05478-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/3a128e18f9b7/molecules-26-05478-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/a02282d59a8a/molecules-26-05478-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/ec9b89d781ee/molecules-26-05478-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/305d358916c3/molecules-26-05478-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/491845d941c0/molecules-26-05478-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e2/8469126/3a128e18f9b7/molecules-26-05478-g005.jpg

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