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新型噬菌体阿里斯托芬编码结构多糖脱乙酰酶。

Novel Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase.

机构信息

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia.

出版信息

Viruses. 2021 Aug 26;13(9):1688. doi: 10.3390/v13091688.

DOI:10.3390/v13091688
PMID:34578271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8471582/
Abstract

appears to be one of the most crucial nosocomial pathogens. A possible component of antimicrobial therapy for infections caused by extremely drug-resistant strains may be specific lytic bacteriophages or phage-derived enzymes. In the present study, we observe the biological features, genomic organization, and phage-host interaction strategy of novel virulent bacteriophage Aristophanes isolated on strain having K26 capsular polysaccharide structure. According to phylogenetic analysis phage Aristophanes can be classified as a representative of a new distinct genus of the subfamily of the family . This is the first reported phage carrying tailspike deacetylase, which caused O-acetylation of one of the K26 sugar residues.

摘要

似乎是最重要的医院病原体之一。对于由极耐药菌株引起的感染，抗菌治疗的一个可能组成部分可能是特定的溶菌噬菌体或噬菌体衍生的酶。在本研究中，我们观察了新型烈性噬菌体 Aristophanes 的生物学特性、基因组组织和噬菌体-宿主相互作用策略，该噬菌体是在具有 K26 荚膜多糖结构的 菌株上分离得到的。根据系统发育分析，噬菌体 Aristophanes 可被归类为 科 亚科的一个新的独特属的代表。这是第一个报道的携带尾刺去乙酰化酶的 噬菌体，它导致 K26 糖残基之一的 O-乙酰化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/4720751ce4bd/viruses-13-01688-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/146502462e68/viruses-13-01688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/d4bfe51f9e30/viruses-13-01688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/e96f5e52667c/viruses-13-01688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/2d017a848628/viruses-13-01688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/6f13c7f049d1/viruses-13-01688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/5bd3ca5d9a2f/viruses-13-01688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/4720751ce4bd/viruses-13-01688-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/146502462e68/viruses-13-01688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/d4bfe51f9e30/viruses-13-01688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/e96f5e52667c/viruses-13-01688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/2d017a848628/viruses-13-01688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/6f13c7f049d1/viruses-13-01688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/5bd3ca5d9a2f/viruses-13-01688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb17/8471582/4720751ce4bd/viruses-13-01688-g007.jpg

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