Stuart Tucker, Kasper Kevin Albert, Iwerunmor Ifechukwude Christian, McGuire Dylan Thomas, Peralta Roberto, Hanna Jessica, Johnson Megan, Farley Max, LaMantia Thomas, Udorvich Paul, Gutruf Philipp
Department of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.
Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USA.
Sci Adv. 2021 Oct 8;7(41):eabj3269. doi: 10.1126/sciadv.abj3269.
Digital medicine, the ability to stream continuous information from the body to gain insight into health status, manage disease, and predict onset health problems, is only gradually developing. Key technological hurdles that slow the proliferation of this approach are means by which clinical grade biosignals are continuously obtained without frequent user interaction. To overcome these hurdles, solutions in power supply and interface strategies that maintain high-fidelity readouts chronically are critical. This work introduces a previously unexplored class of devices that overcomes the limitations using digital manufacturing to tailor geometry, mechanics, electromagnetics, electronics, and fluidics to create unique personalized devices optimized to the wearer. These elastomeric, three-dimensional printed, and laser-structured constructs, called biosymbiotic devices, enable adhesive-free interfaces and the inclusion of high-performance, far-field energy harvesting to facilitate continuous wireless and battery-free operation of multimodal and multidevice, high-fidelity biosensing in an at-home setting without user interaction.
数字医学，即从身体传输连续信息以深入了解健康状况、管理疾病和预测健康问题发作的能力，仍在逐步发展。阻碍这种方法广泛应用的关键技术障碍在于如何在无需用户频繁干预的情况下持续获取临床级生物信号。为克服这些障碍，长期维持高保真读数的电源和接口策略解决方案至关重要。这项工作引入了一类此前未被探索的设备，该设备利用数字制造技术来定制几何形状、力学、电磁学、电子学和流体学，以制造出针对佩戴者进行优化的独特个性化设备，从而克服了这些限制。这些被称为生物共生设备的弹性体、三维打印和激光结构化构造，实现了无粘合剂接口，并纳入了高性能的远场能量收集功能，以促进在家庭环境中无需用户干预的多模式、多设备、高保真生物传感的连续无线和无电池运行。
