Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.
Department of Medical Surgical Nursing, Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, India.
Int J Dent Hyg. 2022 Feb;20(1):136-144. doi: 10.1111/idh.12555. Epub 2021 Oct 29.
A wide variety of mouth rinses are available to combat micro-organisms in the oral cavity. At the present global pandemic, the need of the hour is to control the viral infection due to the novel corona virus SARS-COV-2, as its port of entry is through the receptors located in the oral and pharyngeal mucosa. This systematic literature review focuses on the in vivo studies [randomized control trials (RCTs)] done on the efficacy of existing mouth rinses which have been used in reducing the viral loads.
The electronic database which includes PubMed-MEDLINE, Google scholar, Scopus, Web of Science, EMBASE, ProQuest and CINAHL was searched from December 2019 to June 2021 with appropriate Medical Subject Headings (MeSH) terms and Boolean operators. Two reviewers independently reviewed the abstracts.
Of the 2438 retrieved titles, 905 remained after removing duplicates. Twelve articles were eligible to be included in this review of which seven were randomized with adequate sample size.
Mouth washes containing povidone iodine and chlorhexidine decrease the viral load transiently. Large amount of in vivo studies are of paramount importance, especially RCTs, to prove the efficacy of these mouth rinses.
有多种漱口液可用于对抗口腔中的微生物。在当前的全球大流行中，当务之急是控制新型冠状病毒 SARS-COV-2 的病毒感染，因为它的入口是通过位于口腔和咽粘膜上的受体。本系统文献综述侧重于已发表的体内研究[随机对照试验（RCT）]，这些研究评估了现有的漱口液在降低病毒载量方面的功效。
从 2019 年 12 月至 2021 年 6 月，使用适当的医学主题词（MeSH）术语和布尔运算符，对包括 PubMed-MEDLINE、Google Scholar、Scopus、Web of Science、EMBASE、ProQuest 和 CINAHL 在内的电子数据库进行了检索。两名审查员独立审查了摘要。
在检索到的 2438 篇标题中，去除重复项后仍有 905 篇。有 12 篇文章符合纳入本综述的条件，其中 7 篇为随机对照试验，且样本量充足。
含有聚维酮碘和洗必泰的漱口液可暂时降低病毒载量。大量的体内研究至关重要，特别是 RCT，以证明这些漱口液的功效。
