Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Developmental and Stem Cell Biology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Cell Metab. 2021 Nov 2;33(11):2108-2121. doi: 10.1016/j.cmet.2021.09.013. Epub 2021 Oct 12.
Pluripotent stem cells model certain features of early mammalian development ex vivo. Medium-supplied nutrients can influence self-renewal, lineage specification, and earliest differentiation of pluripotent stem cells. However, which specific nutrients support these distinct outcomes, and their mechanisms of action, remain under active investigation. Here, we evaluate the available data on nutrients and their metabolic conversion that influence pluripotent stem cell fates. We also discuss key questions open for investigation in this rapidly expanding area of increasing fundamental and practical importance.
多能干细胞在体外模拟早期哺乳动物发育的某些特征。培养基中提供的营养物质可以影响多能干细胞的自我更新、谱系特化和早期分化。然而，哪些特定的营养物质支持这些不同的结果，以及它们的作用机制，仍在积极研究中。在这里，我们评估了影响多能干细胞命运的营养物质及其代谢转化的现有数据。我们还讨论了在这个快速发展的领域中，对于日益增加的基础和实际重要性仍存在的关键问题。
