Poerbonegoro Niken Lestari, Reksodiputro Mirta Hediyati, Sari Dewi Puspito, Mufida Thalia, Rahman Muhammad Ade, Reksodiputro Lupita Adina, Audindra Sacha, Yosia Mikhael
Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia.
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Ann Med Surg (Lond). 2021 Nov;71:102909. doi: 10.1016/j.amsu.2021.102909. Epub 2021 Oct 8.
The number of confirmed Coronavirus Disease-2019 (COVID-19) cases in Indonesia had reached 1.4 million cases from a total population of 270 million. Smell and/or taste disturbances are frequently found as early symptoms of COVID-19 patients. Our study aimed to investigate the proportion and characteristics of anosmia and/or ageusia in COVID-19.
This cross-sectional study identifies the proportion and severity of smell and taste disturbances in COVID-19 patients. Subjects were recruited by consecutive sampling. All subjects were required to fill in the questionnaire modified from the American Academy of Otolaryngology-Head and Neck Surgery Anosmia Reporting Tool (AAO-HNS ART). Symptoms severity was measured with a numerical rating scale of 0-10; 0-3 is defined as mild, 4-6 as moderate, and 7-10 as severe.
Out of 51 subjects, 34 (66.7%) suffered from smell and/or taste disturbances. Twenty-nine of 34 subjects (85.3%) suffered from smell disturbance, and 24 of 34 subjects (70.5%) suffered from taste disturbance. Severe smell disturbance occurred in 68.9% of subjects, while severe taste disturbance occurred in 50%. The median onset was three days for smell disturbance and four days for taste disturbance after any symptoms of COVID-19.
Smell and/or taste disturbances were early symptoms of COVID-19. These symptoms commonly occurred within the first four days of clinical onset and frequently manifested in severe conditions.
在印度尼西亚,2.7亿总人口中确诊的2019冠状病毒病(COVID-19)病例数已达140万例。嗅觉和/或味觉障碍是COVID-19患者常见的早期症状。我们的研究旨在调查COVID-19患者中嗅觉丧失和/或味觉丧失的比例及特征。
这项横断面研究确定了COVID-19患者嗅觉和味觉障碍的比例及严重程度。通过连续抽样招募受试者。所有受试者都需要填写根据美国耳鼻咽喉头颈外科学会嗅觉丧失报告工具(AAO-HNS ART)修改的问卷。症状严重程度采用0至10的数字评分量表进行测量;0至3定义为轻度,4至6为中度,7至10为重度。
51名受试者中,34名(66.7%)存在嗅觉和/或味觉障碍。34名受试者中有29名(85.3%)存在嗅觉障碍,34名受试者中有24名(70.5%)存在味觉障碍。68.9%的受试者出现严重嗅觉障碍,50%的受试者出现严重味觉障碍。嗅觉障碍的中位发病时间为COVID-19出现任何症状后的三天,味觉障碍为四天。
嗅觉和/或味觉障碍是COVID-19的早期症状。这些症状通常在临床发病的前四天内出现,且常表现为严重程度。