College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
Biomed Pharmacother. 2021 Dec;144:112299. doi: 10.1016/j.biopha.2021.112299. Epub 2021 Oct 15.
Lamiophlomis rotata (Benth.) Kudo (LR) is an extensively used Chinese herbal medicine. It contains a variety of chemical constituents with significant biological activities that were first recorded in the classical masterpiece of Tibetan Medicine, Somaratsa. In this review, we summarize the information regarding the traditional uses, chemical constituents, pharmacological effects, clinical applications, quality control, toxicology, and pharmacokinetics of LR. At least 223 chemical constituents have been isolated from LR, including phenylethanoid glycosides, flavonoids, iridoids, volatile oils, et al. Their various physiological activities have been demonstrated as analgesic, hemostatic, anti-inflammatory, anti-tumor, marrow-supplementing, anti-bacterial, and immunity-strengthening. The clinical applications of LR and quality control are also discussed, as well as some existing problems. This article aims to provide more comprehensive information on the chemical composition, pharmacological activity, and clinical application of LR, so as to provide a theoretical basis for the further reasonable development of LR in clinical practice and of new drugs.
香青兰（Lamiophlomis rotata（Benth.）Kudo）是一种被广泛应用的中药。它含有多种具有显著生物活性的化学成分，最早被记录在藏医经典著作《四部医典》中。在这篇综述中，我们总结了香青兰的传统用途、化学成分、药理作用、临床应用、质量控制、毒理学和药代动力学方面的信息。至少已经从香青兰中分离出了 223 种化学成分，包括苯乙醇苷类、黄酮类、环烯醚萜类、挥发油等。它们具有多种生理活性，如镇痛、止血、抗炎、抗肿瘤、骨髓补充、抗菌和增强免疫力。本文还讨论了香青兰的临床应用和质量控制，以及一些存在的问题。本文旨在为香青兰的化学成分、药理活性和临床应用提供更全面的信息，为其在临床实践和新药开发中的进一步合理应用提供理论依据。
