Purzycka-Bohdan Dorota, Gleñ Jolanta, Zabłotna Monika, Nedoszytko Bogusław, Szczerkowska-Dobosz Aneta, Sokołowska-Wojdyło Małgorzata, Rêbała Krzysztof, Nowicki Roman J
Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
Department of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland.
Postepy Dermatol Alergol. 2021 Aug;38(4):657-664. doi: 10.5114/ada.2021.108926. Epub 2021 Sep 17.
Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well as pruritus has not been widely investigated so far.
To analyse IL-31 -1066G/A and -2057G/A promoter gene polymorphisms as well as serum IL-31 level and their correlation with severity of psoriasis and pruritus in the population of northern Poland.
The study included 300 psoriasis patients and 186 healthy volunteers. The polymorphisms were analysed using amplified refractory mutation system - polymerase chain reaction (ARMS-PCR) method. Serum levels of IL-31 were measured using the enzyme-linked immunosorbent assay (ELISA) test.
The -1066 AA genotype of the IL-31 gene was statistically more frequent in patients and it increased the risk of psoriasis (OR = 1.80; = 0.04). The GG genotype as well as G allele of the IL-31 -2057 gene polymorphism were rarely observed in psoriasis and were associated with a decreased risk of the disease (OR = 0.6, = 0.007 and OR = 0.7, = 0.01, respectively). Serum levels of IL-31 were significantly elevated in psoriasis patients ( < 0.000001), however, they did not correlate with the studied polymorphic variants of the IL-31 gene, severity of psoriasis, disease onset, presence of psoriatic arthritis and pruritus intensity.
Distinct IL-31 promoter gene polymorphisms may be involved in psoriasis development. It seems that serum concentration of IL-31 may not be a reliable marker of psoriatic pruritus.
白细胞介素-31（IL-31）对银屑病的发展和临床表现以及瘙痒症的影响，迄今为止尚未得到广泛研究。
分析波兰北部人群中IL-31 -1066G/A和-2057G/A启动子基因多态性、血清IL-31水平及其与银屑病严重程度和瘙痒症的相关性。
该研究纳入了300例银屑病患者和186名健康志愿者。使用扩增阻滞突变系统-聚合酶链反应（ARMS-PCR）方法分析多态性。采用酶联免疫吸附测定（ELISA）试验测量血清IL-31水平。
IL-31基因的-1066 AA基因型在患者中在统计学上更为常见，并且增加了患银屑病的风险（OR = 1.80；P = 0.04）。在银屑病患者中很少观察到IL-31 -2057基因多态性的GG基因型以及G等位基因，它们与疾病风险降低相关（OR分别为0.6，P = 0.007和OR = 0.7，P = 0.01）。银屑病患者的血清IL-31水平显著升高（P < 0.000001），然而，它们与IL-31基因的研究多态性变体、银屑病严重程度、疾病发作、银屑病关节炎的存在以及瘙痒强度均无相关性。
不同的IL-31启动子基因多态性可能参与银屑病的发展。似乎血清IL-31浓度可能不是银屑病瘙痒的可靠标志物。
